After zeroing in on the suspect responsible for the bioterrorism that’s gripping Chicago, the PD prepares to undertake their biggest manhunt yet. Upton is torn between helping track down the perp and providing emotional support to the scared young girl that needs her. Voight fears his team is being sent on a wild goose chase.

The crossover starts on Chicago Fire S08E04 Infection (I) and Chicago Med S05E04 Infection, Part II (II).

With the suspects still at large and conditions worsening underground, first responders race to reach the trapped victims, while the investigation into the assailants comes into focus.

The crossover starts on Chicago Fire S13E11 In the Trenches (I) and Chicago Med S10E11 In the Trenches (II).