After a van explodes during a Chicago street festival, a Muslim patrol officer Frank Toma goes missing and evidence quickly piles up pointing to his involvement. Burgess - who helped train Toma - is desperate to prove his innocence, even if that means going against her superiors.

After zeroing in on the suspect responsible for the bioterrorism that’s gripping Chicago, the PD prepares to undertake their biggest manhunt yet. Upton is torn between helping track down the perp and providing emotional support to the scared young girl that needs her. Voight fears his team is being sent on a wild goose chase.

The crossover starts on Chicago Fire S08E04 Infection (I) and Chicago Med S05E04 Infection, Part II (II).