Stardate: 46379.1. Commander Benjamin Sisko and a new crew of Starfleet and Bajoran officers take command of an abandoned Cardassian space station and make an incredible discovery that will change the galaxy and Sisko's future.

A new crew is assigned to a former Cardassian space station: Deep Space Nine. It is a joint Federation/Bajoran force, with Commander Sisko in charge, but his life is dramatically changed when he is declared the Emissary to the Prophets by a Bajoran priest.

Stardate: Unknown. Kira finds her loyalties divided when a Bajoran extremist wanted by the Cardassians comes to the station with questionable intentions.

Stardate: 46421.5. When the return of a man Odo sent to prison years earlier leads to his murder aboard the station, Odo becomes the prime suspect and a target for harassment.

Stardate: 46423.7. A deadly virus created by the Bajorans 18 years earlier inadvertently breaks loose aboard the station, and prompts a race against the clock to find a cure.

Stardate: Unknown. When O'Brien befriends the station's first visitor from the Gamma Quadrant, he learns that the mysterious alien is on the run from determined pursuers.