As Dr. Jenna James looks to move past her hospice scandal, she finds her job threatened by a handsome new doctor and takes immediate action. DiDi is inspired to fight for her union rights, while cutbacks force Patsy to return to floor duty. Dawn questions her marriage and, later, gets some distressing news.

The staff faces an infectious disease crisis. DiDi's family drama spills into work--in the person of her sister-in-law, Yvette. Dr. James reaches out to a pharmaceutical company and finds herself affected by a patient with a complicated past. A worn-out Dawn is revived by Patsy's unpredictable advances.

In the series finale, DiDi walks a picket line in a last-ditch effort to save the Billy Barnes from closing. Meanwhile, Dr. James regrets an offer made in haste; and a student nurse makes a revelation in a secret-sharing session that gets Patsy's attention.