Gintoki, Shinpachi, Kagura and Hasegawa are hospitalized (The Yorozuya gang for food poisoning from eating unfresh crabs; Hasegawa got knocked down by a car). They get themselves involved when a young nurse falls in love with one of her patients.

The trial of Hasegawa's harassment charge comes to a conclusion.

Some Shinsengumi member shows up, and it is soon revealed to be a rival of Hijikata.

The Yorozuya are requested to help a Yakuza boss's son who has become a hikikomori, but little do they know how dangerous this job could turn out to be...

To let the dying dog Kintaro see its owner for one last time, Kagura and Katsura sneak it out of the hospital…only to find themselves caught in the war between the “Planet Eaters” (dogs) and “Planet Pukers” (cats), while Earth’s fate hangs in the balance. Escaping from the Planet Pukers, who are after Kintaro, the two head to the hospital where the old man is hospitalized. Meanwhile, the old man, who is supposedly in critical condition, goes missing. The old man’s children request Gintoki’s services, but when he arrives at the hospital…