The group is hired to find a missing girl. However, the group is dragged into deeper trouble than they originally anticipated. Gintoki may require the help of his old friend Katsura to help him out of this mess.

Gintoki, Shinpachi, Kagura and Hasegawa are hospitalized (The Yorozuya gang for food poisoning from eating unfresh crabs; Hasegawa got knocked down by a car). They get themselves involved when a young nurse falls in love with one of her patients.