Claire and Jamie leave Scotland, sailing to the West Indies on an urgent quest. But when the superstitious crew looks for someone to blame after a string of bad luck, rescue comes from an unlikely source.

Claire races to discover the source of an epidemic aboard a disease-stricken ship before hundreds of sailors die. And as Jamie locks horns with Captain Raines, Fergus finds himself torn between loyalty and love.

As Brianna struggles to compartmentalize the trauma she's suffered in the wake of the tragedy that befell her in Wilmington, she refocuses on finding her parents.

Jamie and Claire keep secrets from one another as they try to help Brianna process her recent trauma. But the secrets they keep cause a bigger familial rift once they are revealed.