After two months of respite, Sarah’s hard-won refuge in Iceland is shattered by a Neolution attack. Once again forced to flee, she realizes no matter how far her family runs it will never be far enough.

After evading a Neolution attack in Iceland, Sarah returns home to track down an elusive new ally. As Cosima struggles with Delphine’s disappearance, Alison and Donnie host a pregnant and ever-hungry Helena. Meanwhile Felix, feeling like an outsider, embarks on his own journey of self-discovery.

When Cosima admits doubts about finding a cure in time to save her life, Sarah makes a lone decision that exposes Kendall to those she’s spent years hiding from. Meanwhile, Art and Felix team up to protect naïve clone, Krystal Godderitch, from herself.

With Susan Duncan deposed, Sarah finds herself in the same position as Rachel — under the heel of a new HBIC — causing the archenemies to come together for the greater good. Cosima and Susan butt heads on the ethical implications of human experiments. Meanwhile, when the Hendrixes' legal counsel, Adele, further investigates Donnie’s case, she begins to suspect Felix is keeping deep secrets. Helena’s arrival forces Felix to make a difficult decision.