Aardvark is out of shape and finds himself too worn out to chase Ant. He returns to his cave where he develops various energy drinks to give him the necessary boost to chase Ant in the jungle. However, increased speed, laser vision, powerful nostril suction, and even boosted intelligence aren't enough to get the better of the crafty Ant. Aardvark actually catches him the old fashion way.

After Aardvark unwittingly gets into a tiff with Eli the Elephant, the pachyderm drops him into a prehistoric subterranean world where aardvarks are significantly smaller than primitive ants. Modern day Aardvark tries to train his prehistoric counterpart on how to catch a giant ant, but their efforts are unsuccessful. Aardvark then gets into a tiff with a wooly mammoth, who knocks him back home to the jungle, before Eli drops him back down to the prehistoric world.

Learning he can't resist parties, Aardvark invites Ant to his birthday party in hopes of making a meal out of him. But Ant is wise to his plan, inviting several of the other jungle animals to join them in what becomes a real party, impeding Aardvark's efforts.

Ant and Aardvark are on exhibit at a zoo. Aardvark escapes his display in effort to get to the Ant's, but has a difficult time when he winds up going through other animal displays, then outside in the general public.

Aardvark tries to catch Ant by using an invisibility spray, but his strategy doesn't work as well as expected, especially when Ant uses it to get the better of him. And things get worse when Aardvark insults a tiger and his mother, and goofs again when he accidentally uses the spray on them, enabling the two to wallop him good.

A sloth offers Aardvark the chance to catch Ant by having him go high-tech in exchange for getting 50 percent of the meal. But efforts of using hypnosis, virtual boxing and portals all backfire, leading Aardvark to give the sloth 50 percent of the pummeling he received from the bear and the herd of elephants who denied him his desired meal.

Aardvark catches a cold and while watching TV, sees an ad for a professional sniffing dog service. He hires one for 3 hours for the purpose of catching Ant, but the hunt doesn't go as well as expected. After spending his day photographing wildlife and the 3 hours are up, Ant hires the pooch to chase Aardvark.

Ant agrees to care for Mrs. Gorilla's baby while she's away for the day. Aardvark uses this as an opportunity to sneak up on Ant, but the baby gets the better of him each time. When mother returns, Ant agrees the baby can keep Aardvark as his new pet as he gets a jar of honey in exchange.