Ethan, now a prisoner under the watchful eye of Scotland Yard Inspector Rusk, is on a train speeding through the desert of the American West. Meanwhile, Sir Malcolm is confronted by a mysterious Native American man in Zanzibar. Back in London, Dr. Frankenstein seeks out his old friend Dr. Jekyll and Vanessa seeks the help of Dr. Seward to battle a new evil.

Lily and Dorian pay a visit to a most unusual show, and Vanessa invites Sweet to a different show. Rusk sets out to track down Ethan and make sure that he hangs, and Henry demonstrates the efficacy of his potion for Victor.

Through hypnosis, Vanessa relives what happened to her in the Banning Institute, including the man who befriended her... and the spirits who tormented her.