London 1891. Renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them search for someone who has been lost.

Vanessa and Sir Malcolm encounter the mysteriously beautiful Dorian Gray at a party. Things take a turn, however, when renowned medium Madame Kali hosts a seance. Meanwhile, Ethan befriends Ms. Brona Croft, a young Irish immigrant.

While Evelyn torments Malcolm, Victor summons Ethan and Vanessa back to London to rescue their friend. Meanwhile, Brona learns Dorian's secret, and Caliban is betrayed.

Vanessa has to use all of her strength to try and defeat the demon.