Yokas clashes with her mother over her recovery; Maritza is back on the job, but unhappy that she's back in the bag and handing out parking tickets; Ty and Sully discover a truck carrying sick illegal aliens and end up scouring the city to track down one of them who escapes after it's determined that the aliens have a highly contagious and potentially fatal disease.

Over her protests, a judge marked for execution is placed under a protective detail and gives Sully and Ty a scare when she slips away to get a cup of coffee; Levine uses an unorthodox way to get a patient's mind off his pain; when no physical reason can be found for Faith's intense pain, her doctor refers her to a psychiatrist; Kim is livid when Doc gives her an official letter of reprimand for disregarding field regulations just the way he did several times; in an effort to get out of the bag and off the street, Maritza convinces Swersky to let her set up a sting operation to catch a chiropractor who's fronting for prostitution, and pays a terrible price for continuing her ""lonesome cowboy"" approach to apprehending criminals.

Sully kills one of the perps and shoots the denotator out of the hand of Frank Morgan, the bomber; Doc goes ballistic when he comes upon the scene of an accident involving his old rig and a city bus, and physically assaults Eugene; Public Morals raids Dr. Chow's office, and Maritza is forced to reveal her rape to keep Thomas Warner from being released on a D.A.T.; Ty gets Frank Morgan to flip on Gary Barnes, and Barbara promises Morgan that she will make sure he gets the death penalty for killing her housekeeper and driver; Kim and Carlos refuse to back up Eugene after he files a complaint against Doc, prompting Eugene to quit; a distraught Faith, still plagued by flashbacks of the shooting, asks Fred if they can get out of the city for a family vacation; Warner confesses to raping Maritza while Bosco is transporting him to the Tombs; Carlos is horrified when Doc admits that he accosted Eugene at his house because he ""killed Taylor""; Bosco turns Warner over to Maritza, who gets her pay

Doc is demoted back to the streets and continues his downward spiral, presenting Kim with no end of problems as he lies about his demotion, resists her orders as the supervising paramedic, and deliberately runs down a perp with the bus; Barnes is shanked at Riker's for doing a flip on Buford; Carlos is devastated when Kylie is diagnosed with aplastic anemia and he's not a match for a bone marrow donation; Sully tries to deflect Ty's teasing about his relationship with Barbara by getting him to focus on their LSAT prep; after a horrific gunfight, Maritza finally captures Lettie's killer and decides to spare him so that he can suffer for the rest of his life in prison.

As Carlos desperately searches for a bone marrow match for Kylie, he digs deeper into his own past and discovers that he wasn't abandoned by his parents, but was found clinging to his dead father's hand after a car accident; after a local station picks up the story, Carlos gets a call from a woman claiming to be his mother; Bosco and Monroe find themselves going after a small-time mobster putting the squeeze on an honest family-run linen company after the son of the linen company owner dies in a suspicious fire.

Bosco arrests a pedophile posing as a toy store Santa, and the grateful store owner returns the favor by helping Bosco and Sasha come to the aid of a man whose house is robbed of all his children's Christmas presents; after Sully and Ty save a young homeless girl from a fire, she rekindles Sully's Christmas spirit; Carlos receives the ultimate Christmas present when his brother arrives at the firehouse bearing the gift of being a perfect bone marrow match for Kylie, as well as the news of Carlos's real name and family history; Kim and Jimmy spend a romantic Christmas Eve together; Sasha's search for the perfect gift for her nephew gives Swersky the opportunity to play Santa.

When Sasha discusses taking the sergeant's exam with Maritza, Maritza reveals that she received her promotion meritoriously, not from passing the test; the police are on high alert after two women are assaulted and robbed by men posing as police officers; Kim and Jimmy decide to keep their blossoming romance quiet until Kim is pulled over by the impostors and narrowly escapes with her life with the help of Bosco, Maritza, Sully and Sasha.

Jimmy gets a promotion to a rescue squad in Brooklyn; despite their new captain's assurances, Doc suspects that he intends to close down the house; Sasha insists upon pursuing an investigation into the beating death of a hit-and-run driver after Maritza uses the confession of an innocent man as her stepping stone to an Anti-Crime reassignment; after Jimmy is trapped in a warehouse fire, Kim reassesses their plans for a future together; Rose's serves a customer at the bar who shares a past with Bosco.

Steeper exiles the paramedics to permanent fixed posts on the street, which upsets everyone on the squad except Doc, who refuses to let anything put a damper on his unusually upbeat attitude; Carlos is less than thrilled when Doc invites Christian to accompany them on a ride-along without getting the proper authorization; when Bosco goes after Nardo for his veiled threats against Rose, Nardo tries to set Bosco up to look like a dirty cop; Rose is fired after Bosco destroys poker machines owned by Nardo in the bar where she works; on the eve of her return to duty, Faith tells Bosco that she wants to repartner with him; Sasha's second thoughts about the plan she and Bosco hatched to repay Nardo for threatening Rose and attempting to frame Bosco turn out to be on target when Nardo flees after murdering two men; Doc and Sasha hook up after Doc throws a big party at his house for his co-workers.

Steeper continues his by-the-books command style and goes head-to-head with Kim when Doc doesn't report for duty on time; Sasha can't find her off-duty weapon the morning after Doc's party; Faith returns to duty at the front desk despite Fred's wanting her to remain on disability, and discovers that Bosco has lied to her about Swersky's not allowing them to be partners; a panicky Nardo kidnaps Rose and then Bosco in a futile attempt to prove that he wasn't a rat, and makes a shocking choice when he realizes that his days as a mobster have come to an end; to the horror of the squads, Doc takes extreme measures to prevent Steeper from closing the house, and forces Carlos and Kim to risk their lives to do the right thing; Sully returns a favor by reaching out and saving his friend's life in Doc's hour of greatest need.

The news that Faith is repartnering with Bosco outrages Fred; Bosco overcomes his initial wariness about his brother's claims of sobriety after the tip Mikey gives him about Ecstasy dealers leads to a solid bust; in the wake of the hostage situation, the department shrink sent to debrief the house elicits a range of emotional reactions from Kim, Carlos and Holly as she reveals that Doc is in the Bellevue psych ward on a suicide watch, and that the toll of 9/11 and its aftermath may be at the root of his collapse; when she investigates the murder of an Ecstasy dealer outside a rave, Maritza discovers that the motive may be a turf war between rival dealers; Bosco is distraught when Maritza informs him that the evidence points to Mikey's being a major Ecstasy dealer who used him to eliminate the competition by providing the tip that lead to the raid; Bosco and Maritza set out separately to find Mikey; tragedy occurs when Maritza and Dade pull over Mikey's car outside a rave.

Maritza goes all out on the hunt for Michael after Dade dies, as does Bosco, who's intent on finding his brother before Maritza does; Faith calls Maritza a liar in front of Swersky when Maritza claims that she saw Michael shoot Dade; Fred is still angry about Faith repartnering with Bosco, and refuses to discuss it; Breene revisits the house and urges the paramedics to talk to professionals or to each other to help deal with the stress of the shootout; looking to collect the reward for information leading to Dade's killer, Anthony tells Maritza where Michael can be found after she lies to him about her relationship with Bosco; Bosco finds Michael moments before Maritza, and his brother claims that he's innocent and that a drug dealer named Spider was Dade's murderer; Spider comes out with machine guns blazing when Maritza, Sully, Ty, Faith and Bosco attempt to arrest him, and a ferocious gun battle ensues; Maritza agrees to work with Michael as an informant after Bosco pleads for his

Distraught over losing an appeal to her suspension, Sasha gets into a car accident that claims the life of a young child; Sully and Ty take the L.S.A.T.; tensions flare between the cops and the firefighters when Maritza goes after J.D., the newbie firefighter, who turns out to be an ex-cop who ratted out Maritza's former partner for stealing drug money; Faith and Fred are still at odds over her return to work; Walsh is promoted to lieutenant; Ty watches over a devastated Sasha, who's racked with guilt over the car accident, Doc's shooting spree, and the events surrounding the deaths of Tanzi and Nardo; J.D. gives Faith and Bosco important evidence he discovered as he put out the fire resulting from Sasha's car accident, which leads the cops to uncovering the basis for the accident and exonerating Sasha.

Wary of Lester Martin, the high-priced lawyer his father has found for Mikey and the deal he's attempting to broker, Bosco warns his brother to stay away from Maritza, but Mikey decides to disregard his brother's advice and makes a deal to become her informant; for good measure, Bosco threatens to kill Maritza if anything happens to Mikey; Sully teases Ty about his budding relationship with Sasha; Faith and Bosco strike a deal with Laura, who also has no love lost for Maritza, to protect Mikey by helping her nab the drug dealers before Maritza gets to them; J.D. offers Kim a ride home, but stops off first at a rave that both Anti-Crime and Narcotics have staked out, thanks to information Mikey gave them; when some bad ecstasy begins to take a rapid toll, the paramedics call for backup, which prompts Maritza and her detail to storm the building; after an arsonist lobs a Molotov cocktail into the crowded building, Faith and Bosco give chase and capture him, while the firefighters rescue

Tensions still run high in the Yokas household; Lester preps Bosco for Mikey's hearing, and then pulls a switch when he cross-examines him on the stand, leading to Mikey's getting RORd; Sully realizes what a toll the job has taken on him by his reaction to the deaths of three people in a robbery at the restaurant where he eats breakfast every day; Faith and Bosco answer a call which leads them to Lester's house, where they find his daughter not breathing; Sully tracks down and arrests the restaurant murderer; after Dr. Hickman tells Faith and Bosco that Lester's wife and daughter have been severely beaten, Lester is arrested; Sully gets his LSAT results; Ty and Sasha get closer.

The Boscorelli family suffers a tragic loss at the hands of Donald Mann, who blames Bosco, Faith and Maritza for the death of his son in a high-speed chase; the Yokas family heads off in different directions; the Martin family splits apart into separate jail cells for the parents, and a return home for Rebecca to the mother from whom she was stolen as an infant; the paramedic family at the 55 gets a new member, Grace Foster, which makes no one involved very happy.

Faith begs Fred to return home, but he refuses for a reason that infuriates his wife; Bosco turns a cold shoulder to Maritza's attempts to offer her condolences; Carlos is spectacularly unsuccessful in his attempts to hit on Grace; on the day of his son's funeral, Donald Mann exacts his revenge with the help of a dirty cop by planting bombs designed to kill the police officers he holds responsible for the death of his son; after Mann's lieutenants force a man to crash a car carrying a live bomb into the funeral home where Mikey's wake is being held, Grace takes charge and goes out of protocol to save Rose's life, and Dr. Fields later swears to have her job for it; Kim's decision not to enter the funeral home while the bomb is still live stems not from cowardice, but from maternal instincts; when Mann discovers that some of his intended targets survived the bombings, he sends machine-gun wielding minions into the hospital to finish off the job.

After a fierce gun battle and some hand-to-hand combat, Mann's gunmen are finally subdued by the members of the 55 in the E.R., but not before Orland is murdered and Bosco is critically injured; after Kim heroically puts herself in the line of fire to save Holly and a little girl, she realizes that her days as a paramedic are over, and that her future lies in being a wife to Jimmy and a mother to their children; Grace and Dr. Fields patch up their differences and come to an understanding about her out-of-protocol field procedures; Maritza uncovers the traitor in their midst, who leads her to Mann; Faith steps over the line to avenge her partner.

Finney continues to press an increasingly reluctant Sasha for information on Faith; Carlos gets nowhere trying to put the moves on Grace; Ty gets promoted to a Field Training Officer and is forced to contend with Brendan, an impulsive and hot headed new police officer who also happens to be Finney's son; after Faith is unsuccessful in getting any of her family members to attend her promotion ceremony, a wired Sasha takes her out for a drink afterward and tries to engage her in conversation about Mann's death; after complaining of boredom, Brendan is forced to watch in horror as a woman is broadsided by two different cars in a terrible car accident; Carlos is spooked after he suffers a series of minor mishaps in the wake of an irate fortune teller's putting a curse on him, and Grace has a little fun with him when she takes full advantage of the situation; Sully tells everyone who'll listen that Finney is a corrupt cop, and that his son doesn't belong in their squad; Holly does a ritual

When it becomes apparent that the body in the dumpster is connected to a series of homicides that Miller investigated on his previous tour, he teams up with Faith, vowing to catch the serial killer and expose the commanding officer who transferred him to prevent him from working on the case; Brendan and Grace hook up; Carlos's plan to visit Holly and tell her that they're not dating doesn't exactly go the way he planned, not that he's complaining; after junkies trying to get the morphine on the bus hold them up at gunpoint, Carlos sustains a head injury trying to protect Grace before Ty and Brendan come upon the scene and Brendan guns down the thief holding a gun to Grace's head; Faith discovers that Miller's situation at home parallels her own; the serial killer stalks and captures his next victim, then arrives at the station house to confess his prior crimes and tell Miller that his latest victim only has twelve hours left to live.

Miller goes on the hunt for Tara Connelly, and Faith tries a series of approaches to get Barton to reveal the girl's whereabouts, until Miller returns to finish off the con that gets Barton to give it up; although they're both still shaken up by the shooting, neither Brendan nor Grace is willing to discuss it or get some counseling; Finney makes sure that his son's shoot comes up clean in the IAB investigation; at Sasha's house, a picture of the knife that Maritza planted on Mann accidentally falls into Ty's hands, but he doesn't realize the implication of his find; over his protests, Carlos gets admitted into Mercy for overnight observation of his head injury, with Holly vowing to stay by his side; a guilty Faith looks on as Finney arrests Maritza for Mann's murder

Internal Affairs drops the bomb on the envelope-pushing Detective Cruz as she is taken away and struggles to survive in jail, while Captain Finney drills Detective Yokas for information that will nail Cruz - but the torn cop secretly knows that she pulled the trigger on a career criminal that frames the case against Cruz. Officer Sullivan reveals more about his running feud against Finney and his rookie son. Carlos and Levine keep getting called to help a suicidal woman. Bosco's condition changes.

Ty rats out Sasha to the squad after Finney refuses to transfer her out; an action star doing research for his next movie goes on a ride along with the firefighters, and Stu quickly discovers that his boyhood hero is a failing alcoholic looking for a chance to revive a dead career; Brendan offers to ride with Sasha when everyone else refuses to do so, which leaves Ty and Sully partnered again; the retired detective who gave Sasha the real I.A.B. file on the death of Ty's father is found murdered by a police-issued bullet; Sully decides to testify against Finney; in pursuit of a drug dealer who shot an eight year old girl, Sasha and Brendan are injured, but the other units in the sector fail to respond to their calls for help until Ty and Sully finally relent and come to their aid.

Everyone in the 55th Precinct faces their worst fears when terrorists are discovered to possibly be building a dirty bomb. Carlos and Levine face trouble in their relationship. Captain Finney decides to end his life, rather than surrender himself for the murder of Ty Davis Sr. Brendan and Davis try to cover it up.

Cruz teams up with Rice to track down the terrorists associated with the possible dirty bomb.

After a suspect in a jewelry store robbery starts displaying symptoms of a disease similar to SARS, the NIH is called in to figure out what is causing this, and hopefully stop this epidemic. Meanwhile, Cruz faces off with a gangbanger, who may have hired a 13 year old boy to carry out a murder.

The crossover continues on Medical Investigation S01E17 Half Life (II)

Cruz connects the dots that link Marcel Hollis to the murder of Darren Maddox, while Marcel begins to organize a street war against the 55th Precinct. Elsewhere, Yokas, Sully, and Bosco track a missing teen to a vampire cult.

Faith investigates Bosco further, Sasha and Ty make up, Cruz goes for some spiritual healing, Carlos meets Holly's parents.

Faith negotiates the end of a live on TV hostage situation. The leader of a vampire cult holds Emily hostage until Bosco saves the day. Cruz attempts to negotiate a deal with a gangbanger to end the war on the 55th Precinct, but instead, he organizes his troops to attack.

The series concludes with the gangbangers taking out their assault on the 55th Precinct. After some grenade explosions, the precinct is destroyed. Cruz knows that Marcel Hollis is behind the attack, and she takes his life, as well as her own. Carlos proposes to Holly, and they are married. Everyone receives their reassignments, and Sully retires. In the last few moments, Sully narrates a look into the future.