In Laceyville, PA, the town barber, Joe Colegrove, and his wife Marlene are thought to be perfect parents with a knack for raising strapping sons. But when half the family is slaughtered in their own beds, all eyes turn to the surviving kin.

In Seminole, FL, police receive two frantic 911 calls from separate members of the Kyne family, each accusing the other of murder.

In suburban Placentia, CA, the Jessee family does battle with cancer, never suspecting another killer lurks within their midst. With survivors pointing fingers at each other, police embark on an epic, decade-long murder investigation.

In Tampa, FL, multimillionaire lottery winner, Jeffrey Dampier, is sharing the wealth with his extended family. But lady luck can be fickle, and this family's red-hot winning streak is soon to end in cold-blooded murder.