In suburban Placentia, CA, the Jessee family does battle with cancer, never suspecting another killer lurks within their midst. With survivors pointing fingers at each other, police embark on an epic, decade-long murder investigation.

In the seaside town of Cary, NC, the Britt family lives a charmed existence until the housing market crashes, igniting a blaze of greed that will leave one family member dead and another behind bars.

The Allman sisters have deep roots in their tight-knit Oakland community. When drug dealers threaten the neighborhood, the family decides to stand their ground. But after their house goes up in flames, one family member hides a smoldering secret.

For the DeWilds of Edgewater, CO, family always comes first. But when one DeWild threatens to break that bond, the find the only way out of this family is murder.

The Bautista family of Riverside, California is living the American dream with a nice home and two hard-working sons. But that dream will soon become a nightmare as one Bautista threatens to sever family ties and somebody loses their head.

For Starkville, MS, couple Joey and Kristi Fulgham, friends and family are one and the same. But when small town hospitality leads to dangerous liaisons, one family member decides the only way out is murder.

In the desert oasis of Tucson, AZ, a beautiful young family's quick climb up the corporate ladder has them flush with cash. But soon, deceit and a cold-blooded murder will turn this family's dream into a nightmare.