Detective Eva Vittoria discovers a pattern of murders when wealthy businessmen begin dying from a mysterious virus and the ICC team’s investigations lead them to a group of art thieves. Meanwhile, a confrontation with the killer puts the whole team’s lives in jeopardy.

When a wealthy teenager is taken hostage, the ICC team has to move fast to track the kidnappers. Meanwhile, Anne-Marie finds a connection to a similar case in Florence as the team races to rescue the boy. Elsewhere, Dorn and Louis soon discover an unexpected link to their arch enemy Alexander Dimitrov, which puts their lives in danger.

While in Florence, Eva finds something amiss when she discovers another similar kidnapping. While confronting her former partner in the Italian Police, a secret is discovered that may put Sebastian's career at risk. Back in Cannes, a search of the financial records from the missing boy's father shows that not everything is as it seems.

When Anne-Marie is away working on an old case, the ICC team must figure out the reason behind a series of shootings in Italy and Slovenia. Meanwhile, two young men have stolen money and drugs from an Italian drug lord and unknowingly kidnap the drug lord's daughter. Eva's past family connections to the drug lord reveal hidden details from her past which may be able to help save the girl.

Genovese returns to New York and becomes involved with human trafficking.

A string of teen suicides that may be linked to Internet bullying are investigated.

The team goes after a gang of black widows who seduce wealthy men into marriage and then poison them.

The team investigates the murder of the press attaché of the Romanian Freedom Party. Marco follows a new lead on his missing sister's case.