While Cooper enlists Red on a case of personal importance, Ressler leads the Task Force on a mission to stop the resurgence of once-dormant murder-for-hire ring. Determined to find answers, Tom disregards a warning to halt his investigation into the suitcase.

As Liz continues tracking Tom's killers, Red tries to solve a tax issue in his money laundering. Meanwhile, Aram goes out to the field when the Task Force investigates a viral outbreak.

Liz uses intel from an unexpected source to force Red to uncover the secrets he holds; Red initiates a plan to retrieve the duffel bag of bones.

Samar lands in the crosshairs of an unconventional Blacklister, and Aram and the task force spring into action to find her before it's too late. Red journeys to Costa Rica to prevent the duffel bag of bones from being sold at an underground auction.

Red acclimates to his new surroundings in federal prison, where he is challenged by an old rival. Samar goes undercover to stop a black market organization that fronts cash to criminals. Meanwhile, Liz and Jennifer continue their investigation into Red's past.