Blade and Shen track down a vampire name Sands, who was used in Marcus's experiments. Krista visits her mom for the first time being turned, she also tries to get a sample of the vaccine and accompanies Chase to a AA meeting.

Krista gets some bad news about her mother. Marcus tries to find a way to get Vanessa back from Blade and sends Krista to Berlin to do so.

Blade tries to solve the murder of a cop named Flanigan who helped care for him while growing up. Flashback scenes tell how Blade's father brought in Abraham Whistler once he could no longer do anything about Balde's need to feed. Krista copes with her mother's critical condition.

Lisa Starr, now a vampire, is on the loose and it's up to Blade and Krista to find her and give her the serum. Chase gets in touch with a old flame name Alex and he wants her to leave Marcus.

After her mother's death, Krista becomes increasingly disconnected from both Marcus and Blade. Blade finds out about the liquid that was taken from Vanessa, while Damek makes his move on Marcus.

Agent Ray Collins and Blade team up to take on the vampires. Marcus finally makes his move on the Purebloods by first going after Charlotte first and then the Conclave.