A krypto-mutant, Gabriel, hacks into missile codes and prepares to eliminate krypto-mutants in Smallville once and for all. A powerless Clark confronts him and is shot, and only Jor-El can save him.

After being shot while stopping a carjacking, the Green Arrow begins acting strangely. Chloe and Clark investigate and find Oliver is taking a super drug that while healing his wound, has some dangerous side effects.