A neurologist who believes that she can communicate with a woman in a persistent vegetative state is murdered by a family member who fears that the doctor will uncover the multi-million dollar motive which led to the woman's disability.

During the investigation into the deaths of several homeless people, Goren and Eames uncover a series of frauds that lead them to a woman in the early stages of dementia and the man who is willing to commit murder to demonstrate his devotion for her.

A world-renowned physicist resorts to murder to avoid being humiliated by his failure to prove a controversial theory of quantum physics that he has spent his career espousing.

A nanny confesses to a murder and an attempted murder that she claims God told her to commit. The link is that both victims lived in the same building, which was poorly constructed, and were rumored to be having an affair.

When Goren and Eames investigate the death of the new owner of a "little black book" once belonging to legendary playboy George Merritt, they uncover the marital indiscretions of a U.S. Senatorial candidate involving sex clubs.

Logan and Barek investigate after a body is found in the ocean, having fallen from an airline wheelwell. They soon discover that she is just one in a long line of prostitutes to be beaten and murdered. Their investigation leads them to a nervous airline employee, but they just don't feel he has the courage or the violent nature to commit these crimes on his own. A family connection leads them to a second suspect, with a history of both being abused and being the abuser.

A boxer celebrating his victory is shot to death, and when it turns out the victim is the brother of a young man Logan mentored he commits himself and Wheeler to solving the crime. Unfortunately, as he and Wheeler explore the world of amateur boxing, secrets and betrayals complicate the case.