The ER treats victims of a gang shootout. Carter arrives late and unprepared for his new position. Mark learns all about being an attending, including senior staff's habit of bad-mouthing the residents, particularly Doug Ross. Mark hires a new chief resident, Kerry Weaver. New third year med students arrive to complete their ER rotation.

Kerry Weaver manages to offend just about everyone in her first day as chief resident. Carol goes on a ride-along with paramedics Shep and Raul, sharing a ferris wheel ride with Shep. Peter and Jeanie's secret relationship comes to a head. Susan is stuck caring for Little Susie while Chloe attends school. Dr. Ross has his hands full with a young pyromaniac. Carter shows interest in med student Harper Tracy.

Dr. Ross treats the dying Chia-Chia. Susan tries to find a way to keep Little Susie, asking her parents for help. Benton treats an injured woman who refuses to press charges against her abusive policeman husband. Carol and Harper are tricked by a patient from the "turkey file." Lydia helps Loretta the prostitute outfit herself for a job interview. The staff celebrates Weaver's day off.

Shep and Raul bring a dozen malnourished and abandoned children into the ER, keeping everyone very busy. Shep has a run-in with Malik and Benton when he makes an off-handed racially insensitive remark. Carter's high from the admission of Mrs. Rubadoux to the study ends when she shows no signs of recovery. Jeanie and Carol clash when Jeanie receives a poor evaluation. Al asks Jeanie to give him another chance. Mark is served with divorce papers.

Benton decides to blow the whistle on Vucelich's unethical study methods, causing Vucelich to drop him from the study. Susan treats a street couple, one of whom has passed HIV to the other. Doug receives a visit from his estranged father. Carter spreads rumors about an affair between Mark and Susan. Mark buys a motorcycle. Prostitute Loretta has cervical cancer.

Mark finds himself manning a very crowded ER on his scheduled night off, filling in while Doug is out with whiplash and Susan meets with her lawyer. He tries to juggle hunger pangs, 40+ patients in the waiting room and a never-ending stream of traumas.

Susan throws herself into her work to escape her stressful personal life, earning recognition from Kerry and Mark, who begins preliminary discussions on next year's chief resident. Carter needs a pedes rotation, and fast, with Doug to graduate med school. Doug takes up with his father's girlfriend. Shep overreacts and attacks an Asian boy interfering at a scene. Mark and Jenn try to discuss their divorce amicably, with unforeseen results. Benton is named Resident of the Year. Harper leaves for an OB rotation at Parkland in Dallas.

Susan visits a psychiatrist to cope with the loss of Little Susie. Jeanie's estranged husband Al checks in the ER complaining of flu-like symptoms, which turn out to be caused by HIV. Shep expects Carol to back his version of events during an official investigation of his behavior. Loretta takes a turn for the worse. Doug discovers that his father has disappeared with a LOT of Karen's money.

Carol is pushed to the breaking point after another day when politics triumph over health care, and she quits. Dr. Greene "trades his soul" when he agrees to back Weaver for ER attending, in exchange for her support of Susan for chief resident. Jeanie takes an HIV test and informs Peter he should get himself tested as well. Carter invites Benton to his med school graduation, which he himself misses. Shep's refusal to see a psychiatrist risks his relationship with Carol.