Lana bets her pink feather pen that she'll sign up more people than a friend will for the Rittenhouse Breast Cancer Walk. She faces some difficulties, however, and goes to extreme measures to get people to sign up. Lu tells a teenaged patient that she is pregnant and she in turn tells Lu that Lu's son Marc is the father. In a shocking ending, the girl reveals a horrifying secret. Andy, meanwhile, takes action when Lizzy's friends receive ""fat letters"" and instead makes the school food healthier when Lizzy starts to severely diet.

Lu and Andy treat 3 patients that have similar symptoms but seem to have nothing in common. Meanwhile, Andy must meet face-to-face with the drunk driver who killed Milo. Andy is horrified when Jesse befriends him after he gives a speech about the dangers of drunk driving at her school. Meanwhile, Jonas is investigated for insider trading. Later, in a shocking climax, Jesse is in a drunk driving accident.