Nick is transferred to Manhatten General. Ben's HIV test has a positive result. Also, Ben hires his ex-wife to make up for the damage he caused to her career. Andy learns that her daughter Jesse's friend is addicted to cough syrup. Kayla Thorton, a new intern, is pushed into the hustle and bustle of the ER. She gets into trouble when she asks a girl if she is sexually active in front of her mother and things go terribly wrong.

Jesse gives her friend CPR to save her life after she loses consciousness due to consuming too much syrup. Andy feels responsible for the incident because Jesse's friend was in her care.

On a stormy Halloween night, a 7 year old girl suffers a serious burn while trick or treating and the only person who could possibly save her life by giving her a skin transplant is her twin sister. Lu must decide if it is ethical to ask the young girl to proceed with such a risky and painful procedure. Meanwhile, Lizzy and her friends witness a crime in the hospital morque while Peter and Lana get the hospital into the Halloween spirit.