Lu treats a young girl for E. Coli who may have contracted E. Coli from eating undercooked food. Lu meets Ben Sanderson, a man who works for the company that owns Rittenhouse and wants to film the doctors as they work in order to get more donations for the RWHC. Meanwhile, Andy treats a woman who has been trying to have a baby and learns a shocking secret about her Southern past. Also, Lana gives Lu and Andy's patients advice, leading to amazing results.

Ben Sanderson wants to cut screening tests for newborns. A patient of Lu's thinks a patient of Andy's is a fugitive but doesn't believe it. Everyone worries if they will have jobs if Octavian Systems takes over Rittenhouse. Andy is asked to stay on a Rittenhouse, and fights for Dr. Jackson's job.

Lu treats a patient who may SARS the doctors tell patents about SRS as they wait for the lab tests. Ben comforts a patient. Andy worries that she will lose Jesse if she moves to California.

Andy tells a famous rock star and a patient to rest and cancel some of her concerts because of fatigue. The rock star invites Lu's young patient who has a terminal disease to spend the day with her. Lu's patient's mother directs a terrible accusation at the rock star. Ben starts a concierge service to keep the clinic open after it faces financial difficulties.

Dr. Campbell treats a patient for what she believes is alcoholism but she won't admit to her drinking problem. The patient's daughter goes to desperate measure to get her mom to stop drinking. Another of Andy's patients needs to get a kidney transplant but nobody in her family is a match. Tammy's mom then reveals a horrible secret that could save her daughter's life. Meanwhile, Lu, Lana, Peter, and Ben go out on the streets to find out what is threatening the lives of young infants.

Andy worries about a patient who continues to ask for surgery to make her breasts perfect even after she has had many surgeries. Andy warns her patient that if she continues to have more surgery she could make it harder for machines to detect a possible sign for breast cancer due to the fact that she has a lot of scar tissue. Andy believes her patient may have a body-image disorder and is worried that her patient could go to extreme measures to improve her body image. Lana's computer breaks down with Marc's thesis on it and Lana, Peter, Ben, Lu, and him must pull an all-nighter to get it done and get the thesis done and turned in in time. Lu must say good-bye when Ben is transferred to Miami and Marc goes away to college.