When a patient of Andy's takes a turn for the worse under Lu's watchful eye, the two doctors butt heads over whether proper procedure was followed. Meanwhile, Andy questions whether or not she can trust her oldest daughter. Also, when Andy and Morton try an experimental xenotransplant (using the heart of a chimpanzee), Peter questions the rights of the animal.

A drug company is offering cash to participants testing a new anti-smoking drug and one of Lu's patients has a very favorable response. An advice columnist Andy is treating loses her ability to read after surgery. One of Bob's daughters needs to be taught swimming for gym class. Lana watches over an elderly senile woman who was left at the clinic with a note. Peter is giving flu shots and a patient has a bad reaction. Andy and Milo Morton have trouble reconciling their busy schedules.