Dr. Campbell files for divorce from her husband while battling a cough. Lu tries to stop a boxer from fighting her next match. Lu tries to get Andy to look at her but she thinks it's just allergies. Andy treats Blain who doesn't feel good.

Lou looks at Lyla who has SIS (Second Impact Syndrome) and wants Lyla to stop boxing because her next match could kill her. Lu heads to the boxing ring to ask Lyla to stop and doesn't listen.

Blain learns she has ATL (Adult T-Cell Leukemia.) Lu tries to track down Andy's chest x-ray thinking she may have Lung Cancer. Dr. Campbell learns she has lung infection.

After Andy saves the life of a gunshot-wound victim, she and Robert must decide whether to accept a donation to the health center from the patient's less-than-reputable father. Meanwhile, Lu helps a breast cancer survivor to overcome her fears about body image and dating after a mastectomy. Also, while planning Jesse's Sweet Sixteen birthday party, Andy must come to grips with the impending financial limitations that her divorce will place on her family. When one of Andy's patients suffers from a heart attack, she and Lu disagree about the cause.