Lu tries to cope with the aftershocks of her rape, she finds her life spinning out of control. Her rage causes Robert to dismiss her from Rittenhouse, and at home her son Marc barely recognizes her. Meanwhile, one of Dana's patients agonizes over whether to continue with in vitro fertilization, which will likely hasten the progress of her deadly disease, LAM.

When Dana's attorneys make Peter's being a sperm donor difficult, Dana considers getting pregnant the old-fashioned way. Lu suspects that a baby's mother is the one responsible for the child's mysterious sickness.

Strange things are brewing at Rittenhouse. A patient seeks Lu's treatment for what appears to be a simple rash; but upon closer examination, the condition turns out to be a dangerous flesh-eating bacteria. Meanwhile, Andy is caught in the middle of a sensitive case when a mother wants to have her schizophrenic daughter's tubes tied. And Peter tries to piece together clues to close the book on a doc who's up to something sneaky.

Andy returns to the Army for reserve duty and helps a woman with post polio syndrome (PPS). Sparks fly for Lu when she is reunited with an old friend whose mother is one of her patients. And when Lana asks if the guy was the ""first"" one Lu answers saying he was the only one.

Lu fears that a little girl who keeps getting injured might be being physically abused by her dad. Andy suspects her nanny is stealing valuables from the house. Peter gets through to an insensitive husband of a pregnant woman about the pains of carrying a baby.

As a heat wave hits Philadelphia, Andy & the staff will need to get used to its disaster plan to cope with heat wave. Claire a patient of Dr. Campbell is told she will develop Alzheimer's disease within 10 years, she also wants to have a baby.

Andy & tells her kids about Dr. Morton, her kids question why she can't make time for kids. Clare worries that her kids might have the gene PGD (the gene that leads to finding Alzheimer's early.)

A young girl with Down's Syndrome tells Lu she shot a girl to get in a gang. The mother later tells Lu that she had her 16 year old (with Downs Syndrome) confess to the crime to protect her sister who actually committed the crime.

Andy and Lu put their heads together when each of their patients show signs of being poisoned. It appears their exposure to chemicals may turn out to have more to do with where they shop. Lu tries to mediate between an alcoholic and the daughter offering a piece of her liver for transplant.

After a policewoman uses a stun gun to discipline an 11-year-old boy with behavioral problems, Lu takes a special interest in him and the new technique. Dylan is asked to perform a risky procedure by a multiple sclerosis patient who is willing to risk her life to beat the disease. Kayla finds that a patient has come into contact with the deadly poison ricin and is forced to report it to the U.S. Department of Homeland Security.