When a 12-year-old girl is diagnosed with oral gonorrhea, she tells Lu (Rosa Blasi) that she got it from her teacher. Lana (Jenifer Lewis) takes on a new role at Rittenhouse: that of patient. Two of Dana's patients deliver babies — and both newborns have the same father.

When Dana's attorneys make Peter's being a sperm donor difficult, Dana considers getting pregnant the old-fashioned way. Lu suspects that a baby's mother is the one responsible for the child's mysterious sickness.

Lu has plenty of opinions when it comes to deciding on Dana's replacement, but she soon learns that Dr. Robert Jackson, the chief of staff, has already hired someone for the position. Enter Dr. Andy Campbell, a former Army colonel who has returned to civilian life for the sole purpose of co-directing the Rittenhouse Women's Health Clinic. It's not long before tempers flare and Andy and Lu butt heads over a case involving a wealthy patient who needs a kidney transplant and a poor woman who sells her healthy organ for the money.

Andy goes beyond the call of duty to expedite the Food and Drug Administration's approval of a drug that could help Robert's wife, who has multiple sclerosis. Also, Andy intervenes when a family is accused of endangering the life of their young daughter. Meanwhile, a woman with terminal lung cancer claims to be Lu's half-sister.

Dr. Campbell's diagnosis of the first local case of West Nile Virus causes a near panic in the community; Lu tries to help a hard-working mother remain close to her hospital-bound son.

Andy helps Jesse cope having back surgery and trying to set things right between her husband. Lu tries to figure out how to spend time with Mickey and Marc. Lu wonders if Mickey would like to live with her.

Andy is worried about whether she should help in her daughter's surgery. Dr. Jackson deals with death of a young girl 6 years ago.

Lu faces the doctor that raped her when he needs surgery that can save his life. Peter goes out with a woman who has terminal diabetes.

Andy and Milo treat a woman with an enlarged heart and conflict about what surgery to perform on her. Lu gets angry with Marc after he stays out until after midnight and insists that she babysit him until he is more responsible. Andy tells a sexually active elderly woman that she has HIV. Lu finds out about a terrible hospital error when trying to find a matching bone marrow for a young leukemia patient. Lana and Peter search the inner city for a woman whose aorta could burst at any time and face some frustrating difficulties.

As a heat wave hits Philadelphia, Andy & the staff will need to get used to its disaster plan to cope with heat wave. Claire a patient of Dr. Campbell is told she will develop Alzheimer's disease within 10 years, she also wants to have a baby.

Andy & tells her kids about Dr. Morton, her kids question why she can't make time for kids. Clare worries that her kids might have the gene PGD (the gene that leads to finding Alzheimer's early.)

A young girl with Down's Syndrome tells Lu she shot a girl to get in a gang. The mother later tells Lu that she had her 16 year old (with Downs Syndrome) confess to the crime to protect her sister who actually committed the crime.

When Lu's (Rosa Blasi) patient receives a desperately needed transplant, Andy (Patricia Richardson) has designs on the discarded liver. Also, when one of Lu's patient's ex-con husband returns home after more than three years in prison, he may be suffering from more than depression. Meanwhile, Andy considers taking her relationship with Dr. Morton (Richard Biggs) to the next level while Lana's (Jenifer Lewis) life is turned upside down when someone from her past returns. Dr. Biancavilla (Brennan Elliott) faces a moral dilemma when a paramedic friend is pricked by an IV drug user's needle.