It's Breast Cancer Awareness Weekend at the Rittenhouse Hospital Women's Clinic, where Lu (Rosa Blasi), Lana (Jenifer Lewis) and Peter (Josh Coxx) are hosting a dance-a-thon and a free mammogram clinic. When one woman's mammogram reveals a lump, she must choose between losing both her breasts and losing her job. After Dana (Janine Turner) delivers the unexpected results of her breast cancer clinical trial, she learns the very disease that's defined her career has now hit too close to home.

A pregnant and very ill pro-life politician has her principles put to the ultimate test when the only treatment that will save her life will result in losing her baby. Meanwhile, a patient of Lu's who is trying to pass herself off as a much younger woman is hampered by the inconvenient arrival of menopause.