The second season begins with Dana and Lu at odds over the fate of a dead college student's fertilized eggs. The day is further complicated by the arrival of Peter's mother, who clings to the idea that her heterosexual son is gay. Elsewhere, a dying patient and her husband wait impatiently for a donor heart and Nick's appointment to the ER staff is in doubt.

Although it is now several months since she was raped, Lu is still reluctant when a cute paramedic asks her out on a date.

Andy helps Jesse cope having back surgery and trying to set things right between her husband. Lu tries to figure out how to spend time with Mickey and Marc. Lu wonders if Mickey would like to live with her.

Andy is worried about whether she should help in her daughter's surgery. Dr. Jackson deals with death of a young girl 6 years ago.

In a surprise twist following the suspenseful season finale cliffhanger, Mickey jumped in front of Lu and took the bullet for her; saving her life. Lu quickly rushes him to the hospital but little can be done to save his life besides putting him on a respiratory machine. Andy and Bob try to convince Lu to take him off the respirator. While Lu deals with the emotional trauma of Mickey's death, Andy tries to perform an experimental procedure on a baby in a bubble but is interrupted by Bob with news that the FDA has un-approved the procedure. Meanwhile Andy gets herself into a bureaucritical battle when she tries to get a patient who has no health insurance a free heart transplant. Also, Andy must tell Lizzy and Jesse that she and Les are getting a divorce and that he is moving across the country.

A friend of Marc's may be being abused by her boyfriend. Lu treats an HIV-infected woman who looks sicker than she is. An obese couple persues gastric bypass surgery. Dr. Jackson sends Nurse Riggs on an unusual assignment that may turn into another career.

Andy and Milo are invited to stay in a beachside cabin owned by a patient of Andy's in a beachside vacation community. The vacation gets interrupted when a young boy suddenly becomes very ill with similar symptoms to Andy's patient who has cancer. Andy is furthur shocked to learn that 9 other residents of the town have died from cancer.

TBA