Emily Owens, an awkward first-year intern at Denver Memorial Hospital, tries to balance work with romance. In the opener, Emily begins her internship and discovers her old high-school nemesis working there, as well as a guy she had a crush on in medical school.

Emily learns that the nurses don't like her when she is assigned a difficult case as revenge. Later, Emily reveals her feelings to Will, and considers using a secret she knows about the chief to get a speedy approval on a procedure.

Emily and Micah are frantic when they discover their patient needs a kidney transplant immediately, but they are baffled when she mysteriously refuses to accept the kidney from her new husband. Elsewhere, Emily assists Dr. Hamada (Brittany Ishibashi) and Dr. Bandari, with a risky surgery after they discover that one of the babies their patient is carrying for her sister suffers from a defective heart valve. Meanwhile, in an effort to keep Cassandra away from Will, Emily tries to land the job as Dr. Bandari’s research assistant. However, her competition is Cassandra, who is willing to play dirty in order to get what she wants.

After a year long absence, Dr. A.J. Aquino returns to Denver Memorial, but before he can rejoin the staff, the Chief insists that he make peace with Dr. Bandari. Emily is tasked with treating a patient who claims to be a psychic, and is convinced that her tarot cards predict her own impending death. Elsewhere, Cassandra and Dr. Bandari treat a patient who needs a lung transplant, but Micah’s discovery of a new medical issue leaves the patient with a tough decision. Meanwhile, Emily decides to test her theory that Will was jealous of her recent date, so Tyra offers to teach Emily how to flirt.