Emily learns that the nurses don't like her when she is assigned a difficult case as revenge. Later, Emily reveals her feelings to Will, and considers using a secret she knows about the chief to get a speedy approval on a procedure.

Emily suffers a major embarrassment in front of her colleagues at the hands of a drug-impaired patient. In the aftermath, Emily decides to follow Dr. Bandari's advice and tries to toughen up. Emily and Will find that a teenage patient needs a partial liver transplant, but they uncover some surprising information when neither of the teen's parents is a match. Meanwhile, Cassandra starts treating Emily better in an effort to learn more about Will, and Tyra sets Emily up on a date with her ex, a fact which she doesn't reveal to Emily.

Emily treats an infant and a deeply religious man whose faith is shaken following surgery. Meanwhile, Will breaks protocol with a risky diagnosis; and Tyra considers telling her father that she is a lesbian.