Mindy decides to cook Thanksgiving dinner at Gwen's house, but she is completely caught off guard when her former blind date, Dennis, arrives with his new girlfriend. Meanwhile, a lonely Danny mans the empty office while Betsy and Jeremy visit Betsy's eccentric family for the holiday.

Mindy's friends and co-workers unintentionally throw her the worst birthday party ever. And, after storming out, Mindy stumbles upon a new group of friends with whom to celebrate. But when she ends up in a fight with her new pals, she receives help from someone in her recent past. Meanwhile, Danny and Jeremy compete for the affection of Mindy's friend.