Alex Pierson, a rising Syndicate member, has recruited Dr. Burke, a psychopathic behavioral psychologist who has developed a way to program men into killers. Pierson lures in underworld criminals with an offer of plastic surgery and turns them over to Burke, who programs them to kill Pierson's targets three times then kill themselves. Barney infiltrates as a crook on the run but when he fails to dose himself with a counter-drug, he is converted into a psychotic killer as well. They lose contact with Barney - Jim plants evidence on Burke making him look like he's turning against Pierson and another IMF agent made up to look like Barney goes after but fails to kill Pierson before fake-killing himself. Pierson confronts Burke while Jim gets the info on Barney's location out of Burke's assistant, and Willy stops the tech expert from killing his target in the nick of time.

Paul Ostro is the head of the Ostro family and a Syndicate member - after a hunting accident leaving him heavily bandaged he announces a new $100 million Syndicate plan and the IMF must find out what it is. It turns out brother Leo had Paul killed and has a substitute placed which he uses to convince four mobsters to contribute a million each into ""Paul's"" mystery scheme. Jim and Casey get Leo involved in an oil deal with a corrupt minister (IMF guest agent Khalid) while Barney as a cook gives ""Paul"" a fake heart attack - Leo has to play along and Willy gets the fake Paul out and they replace him with their own IMF agent Hank and steal the $4 million from the other gangsters. Leo's rival Gault finds the money and a ticket, and when Leo tries to get ""Paul"" to clear him, the IMF agent tells a different story. Leo has to reveal his plan to use the $4 million as the basis for a massive counterfeiting operation and take Gault and the others to his printing presses - the IMF move in and capt