The honeymoon is over for Mike and Sully as the newlyweds must adjust to life in a changing Colorado Springs where a bullish Boston Brahman named Preston A. Lodge III establishes the towns first bank. Preston Lodge III: Jason Leland Adams.

The town invites a traveling all-star baseball team for a fundraising event, but later suspects that they have been swindled. Otis James: Joel Anderson.

Mike is overwhelmed with her new found passion for Sully, and feeling slighted, Colleen joins her schoolmates for dangerous and questionable escapades.

Dorothy Jennings' book about her experiences in Colorado Springs becomes a best seller, but it angers townsfolk.

Dr. Mike celebrates her birthday by climbing Pikes Peak with Dorothy, Grace and Myra, but ends up injured and alone when her companions turn back.

Dorothy, Myra and Grace realize they are quitting and they're letting Mike down, so they decide to go back. They find her injured with a broken arm. Mike can't go to the top of the mountain anymore, but she encourages the others to make it to the top for her. Meanwhile back in town, Preston plots to guild a hotel-casino with help from his ""partner"" Jake; and Robert E is bothered by an encounter with a bounty hunter.

The family finds Matthew running a saloon at a railroad camp where his grief over Ingrid's death drives him to volunteer for a dangerous blasting job. Loren loses Dorothy's money for a new printing press. Peter Chow: Eric Michael Zee.

As Colorado Springs prepares for Christmas, the family receives a rambunctious toy poodle from Mike's mother in Boston, and Brian has a case of puppy love for a new girl in town. The Rev. Johnson recruits folk for a Nativity pageant. Sara Sheehan: Jann Michaels. Mrs. Sheehan: Susanna Thompson.

Increasing lawlessness in Colorado Springs sparks a demand for a new sheriff, and Matthew feels he's just the man for the job. Meanwhile, Brian succumbs to peer pressure shoplifting a toy train from Loren's store. Zachary Brett: Travis Tritt. Charles: John Christian Graas.

Matthew falls for an independent young woman, but the fact that she's a prostitute complicates their blooming romance. Meanwhile, Preston offers Myra a job at the bank, but Horace opposes her taking it. Emma: Charlotte Chatton.

The town is duped by two con men selling shares in a refrigeration box and Mike must turn the tables on the con men, helping the town learn a lesson in trust. Meanwhile, Cloud Dancing barters with Loren to sell corn grown on the reservation at the general store. Randolph Cummings: Brandon Douglas. Curtis Roper: Anthony Lee. Anthony: Brenden Jefferson.

Sully pursues a renegade mountain man who has kidnapped senator Leonard's son, in protest of the Senator's support of Colorado statehood. Meanwhile, Mike is forced to stop her practice when her schedule threatens her pregnancy. Ezra Leonard: Lawrence Pressman. Noah McBride: Denny Miller. Dr. Cassidy: Jerry Hardin.

The rescuers get ugly after Leonard offers a bounty for the mountain man, so Sully sets off alone.

The Reverend mortgages the church to Hank to get money to make church repairs in order to impress his mentor Rev. Thomas. Rev. Thomas: Fred Rogers. Mr. James: Max Gail.

Feelings run high after a drifter is sentenced to hang for rape and murder

Cloud Dancing sees a reservation school as fatal to Indian culture; bankers stonewall Dorothy's loan request.

A popular new arrival carries a dread disease; Preston plans an exclusive clinic.

Cloud Dancing hopes his trial for shooting a soldier will unite the tribes.

Dr. Mike prepares for the birth of her baby. Mike's family arrives for the impending birth of Mike and Sully's baby, bringing along a new young doctor (Brandon Douglas) to help deliver the baby. Meanwhile, Sully is hurt while trying to rescue Cloud Dancing and others from Sgt. O'Connor (Patrick Kilpatrick) and his patrol.

Wounded Sully must deliver Mike's baby. Dr. Cook is forced to perform a major operation. Katie Sully: Alexandria, McKenzie and Megan Calabrese.

Sully goes to Denver to negotiate the release of Cloud Dancing from the army. One of the conditions is that Sully is no longer Indian Agent and may not ever step foot on the reservation again. On the way home the train crashes, injuring most on board. Andrew learns a lesson in humility by watching Michaela in action.

A malpractice suit prevents Dr. Mike from practicing medicine, leaving the reluctant Dr. Cook in charge.

The appearance of renowned singer Gilda St. Clair (Barbara Mandrell) tempts Colleen to leave college and travel the world instead.

A Latin American woman rebuffs Dr. Mike's attempts at friendship; the Rev. Johnson searches for a teacher to take his place. Teresa: Michelle Bonilla.

Dr. Mike is arrested and put in jail for treating a fugitive Indian; Jake and Preston run against each other for mayor of Colorado Springs.

Dr. Mike, Sully and Matthew team up with a legendary marshal in order to nab the thieves who wounded Matthew during a bank robbery.

A severe storm bears down on Colorado Springs, disrupting the arrival of Preston Lodge II and Dr. Mike's attempts to prepare a Thanksgiving dinner.

Grace and Robert E. encounter fierce opposition when they attempt to enroll their son in the town's all-white school.

When three people die after coming in contact with something in the clinic, and one is deathly sick, Dr. Mike, Sully, Colleen, and Andrew but their heads together to find out what it was. They figure out that it was something in the clinic and now it is everywhere. In her case, on the instruments, the sheet. The only solution is to burn everything. When that is done, some are genorous enough to give Dr. Mike some of there things, but they are scared to come in. When Sully must get stitches, and lives after being treated by Dr. Mike, she begins the road to being reaccepted by Colorado Springs.

In a case of mistaken motivation, a judge sends Sully to prison after he is spotted with criminals bent on stopping the construction of a dam.

When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr. Mike looks back on the five turbulent years she's lived and loved in Colorado Springs. As they sit with Andrew, who is mysteriously ill at the clinic, Dr. Mike reminisces about her tumultuous career -- its successes and its failures -- and realizes how many divergent cases she has seen and treated.

When Andrew's condition takes a turn for the worse, Dr. Mike warns Colleen about the fine line between emotional involvement and professional detachment, an issue with which she has long struggled in the frontier town that's now her home.

An old friend of Sully's visits, wanting to financially help the family. Although he falls in love with Michaela.

While Sully is away for a few days to procure some money, Preston arrives threatening to repossess the homestead for nonpayment of the load. Daniel rejects Dr. Mike's objections and pays off the entire loan. Upon hearing how Daniel interfered in his business, the proud Sully becomes furious.

Brian takes a liking to visiting writer Walt Whitman, even when the townspeople shun Whitman over rumors of his alternative lifestyle.

Sgt. O'Connor was found dead in the river. Sully is nowhere to be found. Michaela believes that he survived and goes looking for him. Daniel comes to offer his help. Dorothy and Cloud Dancing share their first kiss.

Cloud Dancing is badly beaten by soldiers for returning late to the reservation. Michaela treats him. When Sully learns of the attack, he is outraged. Tired of being treated cruelly, the tribes plan a rebellion. They enlist Sully's help.

After Marjorie joins the Women's movement she blows into town stirring everyone up and has a fling with Loren.

Everyone is doting on Katie and Brian feels slighted. Brian receives a letter and picture from his real father, which leaves him feeling like he doesn't belong anywhere. Brian starts behaving badly. He gets Anthony to skip school with him and they hop a train. Sully punishes Brian. When Brian questions Sully's actions, Sully says that he is doing it because he is his Pa.

Sully lies to everyone about what he is doing, but the truth comes out. Cloud Dancing flees to the Tongue River Valley. Sgt McKay (David Beecroft)sees Sully at the scene. After Sgt O'Connor (Patrick Kilpatrick) finds out what happens, he goes after Sully. They get into a fight and they both go over a cliff

Sully is found alive, but badly hurt. As Michaela nurses him back to health, she keeps him hidden from the army. Sully sneaks into the homestead one night to spend time with his wife.

Michaela finds out that she is pregnant, but suffers a miscarriage. Without Sully there to comfort her, she has to turn to her friends.

Russian Princess Nizamoff (Natasha Andreichenko) who claims to see the future, tells everyone what they want to hear. Even Michaela is taken in by her.

Marjorie brings a group of Temperance Women (opposed to alcohol consumption) to C.S. Jake goes on a dangerous drinking binge, when he thinks Hank and Teresa are seeing each other. Grace begins to drink heavily to numb her grief. Robert E. moves out.

A diptheria epidemic sweeps through C.S. Michaela performs a procedure that is not a proven cure. Becky (Haylie Johnson) dies.

Mrs. Quinn wants to take to the children to Boston with her. She also disapproves of Loren and Marjorie's relationship. Marjorie contracts the illness. The family sneaks Sully home for Thanksgiving.

Dorothy discovers the deed to the property that Grace's cafe is on. Hank accidently breaks Horace's nose and won't pay for the damage. There is a sudden rash of lawsuits and Michaela acts as Judge.

Loneliness pervades C.S. as the Sweetheart's Dance approaches. Loren sells his store to Preston and plans to move to San Francisco. Jake proposes to Teresa.

Hank captures Cloud Dancing and gets the army to send him to a reservation far away. Jake and Teresa marry, despite her aunt's (Carmen Zapata) disapproval.

Michaela worries about Brian's friendship with an eccentric man (Martin Von Hoffman) who thinks he is a bird.

Robert E releases anger over his separation from Grace through his furious fists in the boxing ring, where he takes on an ailing champ (Richard Roundtree) who's on tour.

Dr. Mike's elation at Colleen's acceptance to medical school quickly turns to disappointment when Colleen chooses to marry Andrew instead. A bitter family argument erupts when Dr. Mike tells Colleen that she is less than overjoyed at her announcement and feels that the couple is rushing into marriage and should wait until Colleen completes medical school. Meanwhile, Robert E and Grace have wonderful news to share; the stock market crash hits Preston and the townsfolk hard; and Dorothy and Cloud Dancing reach a new level in their relationship. As part of the Network's 50th Anniversary celebration, classic footage of James Arness as legendary Marshal Matt Dillon of ""Gunsmoke"" is digitally integrated into this episode. When Jake breaks the news to Hank that he's accepted Preston's offer to buy his share of the Golden Nugget that would make him partners with the despised Preston,