An chemical spill near Dillon High School forces Coach Taylor and the Panthers to seek another facility in which to play the crucial State Semi-Final game.

Tim and Jason go to Mexico as Street hopes to explore experimental surgery. Riggins, who is worried about Street, turns to Lyla Garrity, who's busy helping a newcomer acclimate to Dillon. Meanwhile, Coach Taylor decides on a big career move that will change his life. A development in a police search deeply affects the lives of Tyra and Landry.

Key evidence comes in implicating Landry; when Tami's sister visits to help her with the baby, she stirs things up in the house; Riggins must prove to coach Taylor that he wants to be a part of the team.