When Stocking gets slightly overweight, she goes on an obsessive diet with no such luck. However, she ends up getting fatter, eventually turning into a giant the next day, revealed to be the work of a Ghost.

As a strange pollen causes everyone in town to start picking their noses in ecstasy, Panty and Stocking are invited to a blimp party by Oscar H Genius. However, he turns out to be a Booger Ghost planning to ram into the moon using collective nosebleeds.

The school is taken over by the demon sisters, Scanty and Kneesocks (the daughters of the mayor), and Panty and Stocking aren't pleased with the new changes they have made. In order to get their revenge, they team up with a Loser Ghost, who leads them to an underground factory where the demon sisters are producing Fake Ghosts. Whilst Brief escapes with the Ghoststone powering the factory, Panty and Stocking fight against the demons sisters.

Panty and Stocking find themselves against a horde of zombies who are immune to their angelic weapons.

A music video of the characters singing D City Rock feat. Debra Zeer.

After collecting the necessary Heaven Coins, Stocking manages to return to Heaven. However, due to her erratic sex life, Panty is forced to stay behind and redo her quota, with Garterbelt forbidding her from having sex. She and Brief go to a party, where a devious plan is being concocted by Corset and the Sisters, and Panty finds herself losing her angelic powers.

Brief falls onto Hell's Gate and accidentally unlocks it with Hell's Monkey, unleashing a massive Ghost that begins destroying Daten City. Corset fights and kills Garterbelt and proceeds to merge with the Ghost and try to invade Heaven. Panty and Stocking find a credit card hidden in Garterbelt's afro and use it to buy a device that summons their mother, who seemingly destroys Corset and forces the Ghost back into Hell's Gate, which is sealed by Chuck. Garterbelt returns to life in order to continue watching over Panty and Stocking, who are forced to remain on the surface again due to maxing out his credit card. As soon as they return home, Stocking promptly slices Panty to pieces, revealing herself to be a demon working with Corset, who respawns from Brief's penis.