In Milwaukee, a series of women have been found murdered with their hearts crudely removed. The BAU is assigned to the case, but they are short three members: Gideon, who is missing, Hotch, who is on suspension and Prentiss, who resigns her commission to join the Foreign Service. Supervisor Strauss steps in as lead, but she doesn't handle herself well in the field.

The investigation turns to the family as the BAU and local authorities race against time to locate a young girl who has disappeared from a local shopping mall.

The team searches for a female suspect who uses her professional skills as a high class call girl to lure and kill high-powered executives.

As Rossi, Morgan and JJ profile a killer who is targeting an emergency room doctor, Prentiss realizes that Hotch is missing.

The BAU investigates a case in Rossi's hometown that involves both his personal and professional life.

The BAU team races to help Hotchner find The Reaper and save his family before it's too late.

The team needs to reunite in order to solve a home invasion case, while Agent Hotchner may have to leave the team.

The team searches for a killer who has struck the past three years during Detroit's raucous pre-Halloween celebrations.

Prentiss enlists two former friends from Interpol to track down an old enemy, as Reid discovers clues that could help the BAU locate the parents of an autistic boy.

The BAU is called to a North Carolina resort town after a woman is found badly injured and another woman is missing. On arrival, the team discovers these two women are not the only victims.

Survivors of a Boise high school massacre return to remember the event 10 years later, but the BAU team is called in when a new killer with a similar style targets the survivors. Also, Hotch is worried that his son, Jack, may be a victim of school bullying.

When the BAU travels to Atlanta to investigate the murders of women, the clues lead them to look for an unsub who is not working alone.

When the BAU goes up against a gang of serial-killing bank robbers in Washington, D.C., the team tries to negotiate the situation unfolding inside the bank, but the stakes rise when one of their own becomes a hostage.

As the BAU team continues to pursue the bank-robbing serial killers, the team determines that the suspects have a bigger target in the Nation's capital, and with one of the team still a hostage, they must work quickly to diffuse an explosive situation. Also, wedding bells ring for one of the BAU, and Prentiss ponders her future.

An UNSUB who kidnaps families with the intention of making them admit to and pay for their indiscretions.

When prostitutes in Miami are discovered murdered in a similar style to local animals found dead there, the BAU must work fast to find an unsub whose confidence is quickly escalating. Also, Morgan tries to increase Reid's athletic skills by convincing him to join the bureau's softball team.

The Replicator zeroes in on the BAU when the killer targets one of the team as the next victim. Also, the BAU is called in to investigate a string of deaths in Manhattan tied to apparent ecstasy overdoses, and Hotch discovers that his estranged brother, Sean, is caught in the middle.

As Hotch fights for his life due to complications from his stabbing at the hands of George Foyet, a.k.a. "The Reaper," he experiences visions of his late wife, Haley, and his nemesis, Foyet. Meanwhile, the BAU searches for a missing teenager and investigate her estranged father as a suspect in her disappearance.

Victims of arsenic poisoning are found in Long Beach. The investigation reveals that the killer has a fascination with Greek mythology, based on handwritten death threats to the deceased and other mysterious clues. Meanwhile, Hotch becomes concerned about participating in Jack's third-grade career day.

When a young boy who went missing in San Diego on Halloween suddenly reappears one year later, the BAU must work fast when another trick-or-treater disappears under similar circumstances.

When a Maryland family is found murdered at their dining room table, the team tracks down other family members and friends to uncover secrets that may have led to it. Also, Hotch must try to make peace with his father-in-law, Roy, after discovering he’s been diagnosed with Alzheimer’s.

The BAU is shocked when Hotch is apprehended by a SWAT team and suspected of conspiracy, and as the team scrambles to prove his innocence, they suspect a larger plot is on the horizon.