When the Leader hijacks Iron Man's Hulkbuster suits to destroy the Agents of S.M.A.S.H., the team and Iron Man must learn to trust each other and work together to defeat the Leader.

The Agents of S.M.A.S.H. attempt to help Iron Man subdue Mainframe in a gladiatorial roller derby game for the fate of the planet, but are faced with a challenge when they discover only She-Hulk knows how to skate.

Hulk is torn between his two teams -- the Agents of S.M.A.S.H. and the Avengers -- as both team up to save Earth from a Kree armada led by the Supreme Intelligence.

The Agents of S.M.A.S.H. and the Avengers must work together to free Hulk from the Supreme Intelligence and prevent the destruction of Earth.