With his wounds now healed, Will Graham heads to Europe eight months after the horrific event that almost took his life, in search of closure with Hannibal Lecter. Meanwhile an Italian inspector thinks that Lecter and a killer he pursued 20 years earlier are the same person.

Will Graham continues his search for Hannibal Lecter, making his way to Hannibal's childhood home in Lithuania. Meanwhile, Jack Crawford arrives in Italy, hoping to find Will and intervene before tragedy strikes again, and Bedelia warns Hannibal against unraveling his new life.

The hunt for Hannibal begins. Will travels via train with Chiyoh to Florence, as Alanna and Mason use Hannibal's fine tastes to track his whereabouts. Pazzi tries to get in close to find out if Hannibal is the man he's looking for, but his greed may get the better of him.

With Bedelia securing her alibi, Hannibal prepares to leave Florence just as Jack and Will begin to track him down. With Pazzi murdered, Mason and his cohorts consider a different course of action. However, Chiyoh has arrived in Florence with her own agenda.