When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Will and Jack race to apprehend a serial killer using humans as fertilizer.

A series of family murders takes place.

Jack and Will search for a killer who turns his victims into angels.

The Chesapeake Ripper taunts Jack Crawford with guilt from the past.

Will races to stop a rogue surgeon extracting organs from his victims.

A deadly symphony hall killing forces Will to hunt a defiant killer.

Will, Jack and the BAU team hunt for a serial killer who creates a totem pole out of his victims' bodies.

Will tracks a killer with mental instability similar to his own.

When Dr. Gideon escapes to terrorize Alana and Dr. Chilton, Hannibal and Will go on the hunt. Eddie Izzard guest stars.

Hannibal convinces Jack and Alana that Will could be the copycat killer.

Hannibal frames Will, convincing Jack and Alana that Will's the copycat killer.

With Will Graham in prison, the FBI investigates his claims against Hannibal. A new serial killer emerges.

As the FBI seeks Will's help in tracking a killer who turns his victims' bodies into art, Will plots to reveal the truth about Hannibal.

As Will's murder trial begins, a copycat killer sends a gruesome message. Jack is under pressure to wrap up Will's case while Hannibal hopes for his friend's exoneration.

Emboldened after drug therapy from Dr. Chilton, Will sets a deadly plan in place to expose Hannibal. A new killer is turning victims into beehives.

The BSU investigates Beverly's death after her body is found displayed in a gruesome tableau. Abel Gideon returns to the Baltimore Hospital for the Criminally Insane. Will seeks a horrific revenge for Beverly's death.

Jack suspects Hannibal might be the Chesapeake Ripper as two more victims turn up. Hannibal and Alana distance themselves from Will.

As Miriam Lass begins her recovery, Will is released from prison and resumes his pursuit of Hannibal.

Will resumes his therapy with Dr. Lecter. The FBI investigates the murder of a woman whose body was found sewn inside a dead horse.

Margot Verger seeks out Will as she tries to understand Hannibal. The FBI searches for an animalistic killer who tears his victims' bodies apart.

Will's readiness to go to dark places strengthens his bond with Hannibal.

Will and Margot hide her pregnancy from Mason. After Freddie's gruesome murder, Alana's doubts about Will and Hannibal grow stronger.

Dr. Hannibal Lecter has been under lock and key for three years at the Baltimore State Hospital for the Criminally Insane, when a new villain arises in Francis Dolarhyde, also known as "The Tooth Fairy." As the investigation unfolds Jack Crawford approaches Will Graham to help catch this vicious serial killer who is targeting families.

The FBI's search for elusive serial killer Francis Dolarhyde intensifies as Will Graham begins envisioning himself in Dolarhyde's tormented psyche. Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the killer's profile. Meanwhile, Alana Bloom reminds Will that the last time that he and Hannibal worked together things didn't end well, but Will sees no other option. Elsewhere, a new woman comes into Dolarhyde's life.

Convinced that the Red Dragon will strike at the next full moon, Jack and Will grow desperate, and Alana turns to Hannibal for help.

In a desperate bid to slay Francis Dolarhyde, Will Graham engineers a cunning ploy utilizing Hannibal Lecter. Upon learning of his plan, Bedelia Du Maurier voices concerns that Will's actions may not only put his life in peril, but the lives of those around him. As the end draws near, Will remains unflinching in his game with Hannibal-even when it means coming face-to-face with his own darkest fears?