When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Will and Jack race to apprehend a serial killer using humans as fertilizer.

Abigail Hobbs comes out of her coma with new information about her father.

A series of family murders takes place.

Will races to stop a rogue surgeon extracting organs from his victims.

Will, Jack and the BAU team hunt for a serial killer who creates a totem pole out of his victims' bodies.

Hannibal convinces Jack and Alana that Will could be the copycat killer.

Hannibal frames Will, convincing Jack and Alana that Will's the copycat killer.

Emboldened after drug therapy from Dr. Chilton, Will sets a deadly plan in place to expose Hannibal. A new killer is turning victims into beehives.

Springing their trap, Jack, Will and Alana face off with Hannibal in a bloody final showdown, but the doctor has a few surprises of his own.

After the devastating bloodbath at Lecters home Hannibal establishes a new life for himself in Italy along with the company of his own psychiatrist Bedelia.

With his wounds now healed, Will Graham heads to Europe eight months after the horrific event that almost took his life, in search of closure with Hannibal Lecter. Meanwhile an Italian inspector thinks that Lecter and a killer he pursued 20 years earlier are the same person.

The FBI's search for elusive serial killer Francis Dolarhyde intensifies as Will Graham begins envisioning himself in Dolarhyde's tormented psyche. Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the killer's profile. Meanwhile, Alana Bloom reminds Will that the last time that he and Hannibal worked together things didn't end well, but Will sees no other option. Elsewhere, a new woman comes into Dolarhyde's life.