Two teams: Northeastern Spirit Society of Fairmont, WV and West Virginia Paranormal of Morgantown, WV search for ghosts inside the "Sugar Shack", psyc ward, and boiler room in the abandoned West Virginia Penitentiary (aka Moundsville State Penitentiary), which is said to be haunted by an angry former inmate nicknamed the "Baby Raper".

Two teams: E.P.I.C. Investigators (Theresa, Darla, and Cathi) from Cleveland, Ohio and Dark Alley Paranormal (Brian, Alex, and Aaron) from Columbus, Ohio investigate Waverly Hills Sanatorium, an abandoned tuberculosis hospital which documented thousands of deaths during a tuberculosis outbreak in the early 1900s, where high casualties led to the construction of the "body chute".

Two teams from West Virginia go head to head: Tony, Jeff, and Matt of Appalachee Paranormal and Jackie, Mandy, and Stacey of G.A.L.S. Paranormal (Ghosts, Apparitions, and Lost Souls) investigate the Trans-Allegheny Lunatic Asylum, a former psychiatric hospital that is believed to be one of the country's most haunted sites.

An abandoned hospital near Chattanooga, Tennessee is investigated by two teams: Office of Paranormal Studies and Tennessee Wraith Chasers.

Amateur ghost hunters explore La Purisima Mission in Lomboc, Cal., where a bloody Indian uprising occurred in 1824.