Fast-talking New Yorker Zoe Hart has her life all figured out until she is turned down for a prestigious fellowship she had been certain she would get. Desperate, she decides to finally accept the offer of a kindly stranger, Dr. Harley Wilkes, whom she met at her medical school graduation, and who had proposed she join his small medical practice in Bluebell, Alabama.

Zoe tries to win over residents of Bluebell by participating in the Founder's Day parade, but an unfortunate incident only makes matters worse.

When Nascar’s Brian Vickers has to drop out of hosting Bluebell Junior League’s annual turtle race, Lemon is reluctantly convinced that the mayor is the perfect replacement as her co-host. Zoe is asked out on a date by a handsome local veterinarian, Dr. Judson Lyons. Wade has an unexpected visitor who stirs up all kinds of trouble for him.

Zoe decides that it’s too soon in her relationship with Judson to go to the annual Sweetie Pie Dance so instead she makes plans to have a sleepover with Rose, whose parents are going out of town. George misplaces the save the dates for his upcoming wedding which causes major trouble in Lemon paradise. Lemon wants her father to finally move on from her mother leaving him, so she secretly gets him a date for the dance.

After a wild night of partying, Wade wakes up with a massive hangover, an uninvited houseguest and no memory of what happened the night before. Meanwhile, George takes an unplanned roadtrip to New Orleans, and Lemon finally confesses her troubles to her father, Brick.

With an impending storm about to hit Bluebell, George and Lemon prepare for their wedding day. Meanwhile, taking shelter from the storm, Zoe finds herself stranded in a barn with Wade.

After George confesses his feelings to Zoe, she finds herself having to make a tough decision between George and Wade, leaving the two guys at odds on how to handle the situation. In search of some much needed girl advice, Zoe makes a new fast friend in former BlueBell resident Ruby Jeffries, who no one is excited to see. Lemon decides it’s time to get her own apartment and a job, but it’s tougher than she thought. Continuing to forge ahead with her new life, Lemon proceeds to return the wedding presents, but a sudden detour to Zoe’s while holding a cake knife creates a stir with the townspeople.

Zoe (Rachel Bilson) finds herself anxious that her ever-critical mother will be visiting BlueBell soon for the holidays. In order to avoid spending quality time with her mother, she busies herself with a patient, but potentially ruins Christmas Eve for the whole town.

With the sudden nuptials of Wanda and Tom in BlueBell, Zoe agrees to be maid of honor, which entails the difficult job of watching Wanda’s crafty mother. Zoe uses her wedding duties to try to avoid the awkwardness between her and Wade, but has a feeling something is wrong. Lemon faces the memory of being left at the altar and decides to take matters into her own hands. Meanwhile, Lavon hears about the neighboring town trying to build a shopping mall next to their local beach and he enlists George’s help to fight it, but an unexpected side of George rears its ugly head.

When the town decides to put on a performance of Shakespeare's most iconic scenes, George and Zoe refuse to play Romeo and Juliet, but eventually agree just to prove to everyone that they are over each other. Lemon and Wade are excited about taking over the reigns at the Rammer Jammer, but things come to a halt when they lose all the staff two days before opening. Meanwhile, Brick decides to offer a week of free counseling to everyone in BlueBell and winds up helping the two most unlikely people, but in his effort to help others he learns a secret he has been keeping from himself.

After having a rough time in BlueBell, Zoe decides a little time in New York City might be the perfect opportunity to give her some much needed perspective. But a medical emergency on the plane forces her to complete the trip with an unexpected companion. George struggles with his constant relationship misfortunes, until he runs in to Lily Anne, who helps him with his heartache. When Lemon promises that the Rammer Jammer will be having a special concert with the band Gloriana, she must scramble to make it happen, with the less-than-enthusiastic help of Wade. Meanwhile, Lavon discovers that the opposing town's Mayor has stolen something dear to him and enlists the help of the townspeople to get it back.

After spending the summer in New York City, Zoe is ready to make her move more permanent, but first she must return to BlueBell for one last thing. Upon her return Zoe, discovers that no one in town is very happy to see her, except for Lavon. Desperate for Brick to give her a good reference, she agrees to help him track down George and get him to resurrect the Founders Day parade that has been canceled. Needing to find George quickly, Zoe enlists Lemon’s help but accidentally discovers Lemon is hiding a dirty little secret. Meanwhile, Lemon also devises a plan to help Wade save face in front of Zoe.

When Zoe finds herself treating her uncle, she takes a chance and invites him to the Hanukkah celebration that she is hosting. However, this lands her in trouble once again with Vivian Wilkes. Lemon enlists George and Lynly to help uncover crucial information about one of Brick's exes before he does anything rash. Meanwhile, Wade has a horrible toothache but refuses to go to the dentist, until Tansy intervenes and helps him to open his eyes to his future.

Zoe and Joel are frustrated by all the snags they keep running into while trying to remodel their new home. Rose persuades Lavon to agree that BlueBell will be sister cities with a town in France. Lemon convinces George to help her out with a business venture, but in order for things to go smoothly, Wade has to play peacemaker. Meanwhile, Brick sees an opportunity to become BlueBell's Man of the Year, but he soon discovers he has some tough competition.

Zoe tries to be a supportive friend to Wade, but when she makes a grand gesture, Wade is forced to make a tough decision about his future with the Rammer Jammer and BlueBell. Lavon and George meet their hero Don Todd, who helps them see things in their life more clearly. Grandma Bettie tries to convince Lemon that she has to take her search for a suitable husband more seriously. Meanwhile, AnnaBeth is trying to picture her future with Davis.

Zoe is happy that Wade has decided to stay in town, but struggles to get him to notice her romantic gestures. Someone from Brick's past pays him a visit. Lavon and George want the same thing.

Zoe and Wade feel unprepared for parenthood; a surprise shakes Brick to the core.

As Zoe and Wade try to work out their issues, Zoe makes a life-changing decision and Wade does everything he can to make it happen before their baby is born. Lavon feels guilty about misleading Lemon and is determined to make things right. Meanwhile, George and AnnaBeth are frustrated with their current situation, leaving them with a big decision to be made.