Jessie, Bertram and the kids head to Bali for a family vacation, but when their private jet starts to experience difficulties, Jessie takes control of the cockpit and makes an emergency landing on a tropical island. Jessie must figure out how to get the kids home safely, all while recovering from poisonous bug bites, escaping scary monsters and tracking down Mr. Kipling.

Mr. Kipling has been acting strangely for some time. He is mean to Ravi and is having wild food cravings. It is revealed that Mr. Kipling is a female lizard guarding her twelve babies, and this startles the entire Ross family. Meanwhile, Zuri is upset when she announces that Millie the Mermaid has died (she accidentally got stabbed by a swordfish). The mailman accidentally ships Mr. Kipling's eggs to a restaurant. Jessie, Ravi, and Luke pretend to be waiters and try to get them back. At the restaurant, the eggs hatch and twelve little lizards are born. The episode ends with the entire family, including Bertram, attending Millie the Mermaid's funeral.