SpongeBob and Patrick decide to build an indoor miniature golf course in SpongeBob's pineapple house after it has rained outside. Squidward, who was sleeping and annoyed, tells the two to keep the noise down in constructing the course. They must not disturb Squidward, while Patrick distracts SpongeBob to make him lose in the process.

When Patrick suddenly grows a beard, he decides it is time to act like a grown-up. He tags along with Squiward, who offers to teach him everything he knows about how to be mature, much to SpongeBob's dismay.

SpongeBob and the gang, including Patrick, Mr. Krabs, Squidward, Sandy Cheeks, Plankton and Karen, and Gary, participate in a sled worm race for one million dollars. However, just before the race begins, Plankton sneaks off to the Krusty Krab and uses a robot as his replacement in the race. Plankton goes inside the Krusty Krab to steal the Krabby Patty formula, while the group must keep a yeti, who is attacking them, away.

When Squidward gets hurt on the job, he menaces to take legal action unless his employer, Mr. Krabs, agrees to cater to him to his every need. Mr. Krabs, who eventually gets tired of doing everything for Squidward, hires SpongeBob and Patrick to investigate the scene.

Instead of paying money to repair a hole in the wall of the Krusty Krab, Mr. Krabs decides to use it to gain more income by turning it into a drive-thru window. However, his two employees, SpongeBob and Squidward, have difficulty in keeping up with orders, which results to wreak havoc.

Plankton tries to befriend Squidward in order to get the Krabby Patty secret formula. However, Squidward refuses to discourse with him until SpongeBob tells Plankton that he must compliment Squidward's music in order to strike up a friendship. The two become friends and share their music to all of Bikini Bottom.

The night before a school dance, Pearl gets a barnacle on her face. Mr. Krabs asks SpongeBob to help his daughter remove the blemish to save money, instead of taking Pearl to expensive treatment.

SpongeBob and Patrick learn the secret origins of Mermaid Man and Barnacle Boy from the heroes themselves.

SpongeBob gladly accepts to house sit Sandy's Treedome, while she is away. Sandy first shows SpongeBob what he should do, and all is quiet until Patrick arrives for a visit. The best friend causes chaos and wreak havoc, which results to the house getting destroyed.

SpongeBob and Patrick find a houseboat haunted by a crew of ghost pirates headed by Lord Poltergeist. The two get caught in a feud between them and the Flying Dutchman.

When feeling that he is doing the same activities every day, Patrick moans that he needs a break. SpongeBob suggests a vacation out of town, which cheers him. When at a travel agency, Patrick is given options, but they are thrown out when it is revealed that he cannot afford a trip. SpongeBob comes up with a solution—a "staycation", a vacation at home—which delights Patrick.

SpongeBob meets Sandy, who is preparing her rocket to go to the Moon for a vacation. However, SpongeBob accidentally stows away, and when on the Moon, the two set out camp. SpongeBob and Sandy play sports including sandboarding on its craters. After accidentally crashing the sandboard into the fuel tank, they immediately start the rocket because they need to return home before the fuel runs out.

SpongeBob invites Mr. Krabs, Pearl, Sandy, Mrs. Puff, Larry, Squidward, and Plankton to watch a slideshow of his family vacation to the Great Barrier Reef. In the slideshow, SpongeBob and his parents are on a family road trip with Patrick, but the two best friends get lost and end up in a forest for adventure.

After making bubbles with hot sauce, SpongeBob and Patrick accidentally destroy Sandy's air supply by causing a fire and fill her Treedome with water by contaminating it. They must help her find enough oxygen in order to help them breath. In the end, SpongeBob goes to the surface to create a giant air-filled bubble, and puts it into the Treedome.

While looking for spare change, Mr. Krabs notices an over-sized soybean at Sandy's Treedome. Mr. Krabs is interested in what could have enlarged the plant, and Sandy revealed an experimental growth formula, which Mr. Krabs steals out of sight. At the Krusty Krab, he uses the growth formula on a Krabby Patty, but it keeps on growing until chaos erupts.

Squidward tries to find his happiest memory, but gives up after hope is lost. Desperately, SpongeBob "helps" him create one.

A fed-up Squidward has had it with SpongeBob's annoying antics, pranks, wisecracks, and practical jokes and issues SpongeBob a restraining order against his neighbor. SpongeBob is afraid that he will violate the restraining order again. (According to this restraining order, SpongeBob is not allowed to come within 15 feet of Squidward, lest he end up going to jail for the rest of his life.)

Plotting to ruin Mr. Krabs, Plankton, his business rival, drives away his customers. As a result, Mr. Krabs is forced to give out free Krabby Patties in order to try to win them back.

When Plankton replaces his computer wife Karen with an upgrade called Karen 2.0, the original Karen leaves and gets a job at the Krusty Krab.

SpongeBob brings home a box of new snail treats that Gary will do anything to get – especially when they run out.

SpongeBob and Patrick get face freeze after making too many faces despite being warned not to by Mr. Krabs.

When Squidward goes home sick with a fake illness, SpongeBob thinks he has caught it for real.

A concert promoter named Colonel Carper wants SpongeBob and Squidward to form a band together and send them on a "world tour". However, the greedy Mr. Krabs decides to manage them in order to make his own profits from his to employees' success.

Mr. Krabs wants all of Bikini Bottom to eat at the Krusty Krab, so SpongeBob and Patrick go on an advertising blitz.

Plankton teams up with Man Ray to get the Krabby Patty formula and rule the world.

Plankton turns everybody in Bikini Bottom from nice to naughty by feeding them his special jerktonium-laced fruitcakes and transforming them into donkeys in his attempt to get his Christmas wish—the Krabby Patty secret formula. However, it is revealed that the only victim capable of surviving the mineral is SpongeBob because of his massive love for the holidays which makes him immune to the effects of jerktonium.