The Straw Hats arrive on Future Island Egghead along with Jewelry Bonney, who is looking for Dr. Vegapunk. But while they are meeting the various Vegapunk Satellites, CP-0 arrives and Luffy learns of the plot to assassinate Stella and agrees to help him off the island. Meanwhile, Cobra and Sabo learn of a terrible truth at Mary Geoise and Koby escapes Beehive with the help of Vice Admiral Garp.

As the news about Garp’s disappearance and Luffy’s hostage situation spreads, a mysterious earthquake suddenly shakes the entire world. Meanwhile, a huge Navy fleet led by Admiral Kizaru surrounds Egghead and listens in as York contacts Mary Geoise to negotiate a deal.

In the Labophase on Egghead, which is completely surrounded by the Navy, Luffy and the others devise a plan to escape the island. However, the Frontier Dome, the laser defense system, cannot be deactivated without York’s secret passcode.

Navy Admiral Kizaru finally makes landfall on Egghead and Sentomaru, Vegapunk’s bodyguard, stands in his way. The two men who were once close now clash violently. Meanwhile, Luffy and the others try their best to move the Sunny to the back side of the island to escape.

Kuma finally reaches Mary Geoise and keeps advancing even without free will or mind. But Fleet Admiral Akainu stands in his way. On Egghead, Kizaru enters the Labophase and delivers a powerful kick to Luffy who tries to stop him.

A bizarre battle between Luffy and Kizaru heats up. Meanwhile, in the Fabiriophase, Bonney is all alone and being chased by the Navy soldiers. Dr. Vegapunk sees this and can’t help but leave the Labophase to rescue her, risking his life.

Vegapunk successfully wrests back the Pacifistas from the Navy, but another party soon gains control of them. At the same time, Luffy, Zoro, and the others sense an unearthly presence just as a pentagram suddenly appears on Egghead.

Chopper and Carrot review the history of Bartholomew Kuma and Bonney. They talk about how they were involved with the Straw Hats in the past, the special bond between them, and the commotion they are now creating at Mary Geoise and Egghead.

Bonney gets captured by St. Saturn, whose enigmatic power keeps Sanji and Franky from saving her. In St. Saturn's clenched fist, she recalls the memories of her father, Kuma. 47 years ago, Kuma was born to a father of a race on the verge of extinction.

The human hunt begins and the Celestial Dragons start chasing locals of God Valley and slaves for prizes. Ivankov and Ginny share with Kuma and the others their surprising plan to survive the game. Meanwhile, ships full of infamous pirates start arriving on the island one after another.