After surviving the attack by Colleen, Sean's physical and emotional well-being are still feeling the effects. Meanwhile, Christian receives some disturbing news after lending Liz some moral support with her breast cancer scare.

After being rejected by Kimber on account of his post-surgery scars and with his chemotherapy making him sick, Christian seeks support from Liz, which leads to a surprising sexual encounter between them. Sean discovers his new lover (Jaime Ray Newman) has a disturbing fetish, and further alienates Julia and Matt when they learn that he has been faking his need for a wheelchair. Raj has a life-altering sexual encounter with the wife (Beth Gargan) of McNamara/Troy's latest patient.