Black Jack finally arrives in England to hear of a man who's been in a coma, unaged, for 65 years. Dr. Stein wants to analyse him to find out why he hasn't aged, thinking it will give them information about eternal youth; but the patient's niece has hired Kiriko to put an end to it. Black Jack operates, but afterwards the patient ages and dies upon finding out that his family had died.

Black Jack is now in Canada. He goes into the mountains to find Dr. Jorujyu's research lab. The Lady that has been trying to kill him was injured and he decided to helper. An avalanche suddenly happens and traps all three of them in the cellar. The document that he finally finds, that was about the phoenix disease, ends up being lost in the snow.

Black Jack tells Dr. White to change course to the North Pole, meanwhile Renka start her plan in getting the Phoenix Disease. Later the Sky Hospital receives a call from the US Alaska base, and are told that Doctors from all the world are trying to find the cure to the Phoenix Disease, one of them being Dr. Kuma revealing that they only have 21 hours to cure or die. The National Security manager is told that they are going to launch a Nuclear Missile to rid of the Virus and as well of those ill from it. Renka gets on the Sky Hospital. Just before Renka about to shot Black Jack, her father interfere, they both shot each other, Zen Mantoku died and Renka injured badly, Black Jack decided to operate Renka, anyway. When operating Renka Black Jack finds the cure to the Phoenix Disease. The missile has been shot without any way to making it to don't crash on North Pole. While the Phoenix Disease continues to spread in Black Jack's body, he questions himself why he is saving Renka's life.