日暮戈薇在15歲生日當天被妖怪百足妖婦拖入自家神社的食古井內，穿越到了戰國時期的村莊，巫女楓姥姥發覺戈薇和去世多年的姐姐——桔梗極其相像，認為她很有可能是桔梗的轉世。百足妖婦再次來襲，並且打傷了戈薇，本該隨著死去的桔梗一同火化的寶物四魂之玉，從戈薇體內出現。為了避免村莊受到傷害，戈薇單獨把妖怪引到了被桔梗封印的半妖犬夜叉所在的森林，不得已之下解開了犬夜叉的封印，獲得自由的犬夜叉殺死百足妖婦後也打起了四魂之玉的主意……

楓姥姥（桔梗的妹妹）拿出言靈念珠阻止了犬夜叉奪取四魂之玉，戈薇只要說出言靈“給我坐下”便可製服犬夜叉，礙於念珠的能力，犬夜叉無法下手，只好徘徊在戈薇身邊。犬夜叉得知自己被封印之後已過了50年，而穿越時空來到戰國時代的戈薇則很可能是死去桔梗的轉世。戈薇在找回家的方法時陷入屍舞鳥的攻擊，失手將被屍舞鳥吞下的四魂之玉也一同射穿，四魂之玉化成無數碎片劃過天際。

楓姥姥告訴犬夜叉和戈薇只有通過兩人的合作才能尋回散落的四魂之玉，戈薇在和犬夜叉鬧彆扭後，獨自一人跑到食骨之井旁尋找回家的路，卻遭到了試圖奪取四魂之玉的妖怪逆發結羅的攻擊，落入井中回到現代。另一方面逆發結羅用頭髮操縱村子裡的人使犬夜叉陷入苦戰。犬夜叉背著受了重傷的楓姥姥逃出村子，楓姥姥告訴犬夜叉只有戈薇的眼睛才能看的見頭髮，為了打敗逆發結羅，犬夜叉開始尋找戈薇。

回到現代的戈薇本以為再也不用去戰國時代，正安心吃飯時，卻看見了犬夜叉闖到家裡來，還看見了跟著犬夜叉一起跟來的逆發結羅的頭髮。為了不禍及家人，戈薇便和犬夜叉一起回到了戰國時代。戈薇披著犬夜叉的火鼠袍，循著頭髮，指引犬夜叉找到逆發結羅。又是一番苦戰，戈薇用箭敲碎逆發結羅的真身——藏在紅色骷髏裡的梳子打敗逆發結羅，拿回了被奪走的四魂之玉碎片。經過了這一戰兩人的關係也開始有了好轉。

犬夜叉的哥哥殺生丸與他的手下邪見突然出現，他一心想尋找父親墓地裡的寶物，守墓人冥加爺爺十萬火急地趕來通知犬夜叉。沒想到殺生丸隨即找上門，而且還帶來一個與犬夜叉的母親十分神似的女人……

原來犬夜叉的母親是妖怪無女假扮的，她是失去孩子的母親怨念聚集而成的妖怪，殺生丸利用無女問出了父親墓地的線索，兩人便在墓地中展開了一場寶物爭奪戰……

殺生丸與犬夜叉都無法拔出來的鐵碎牙，沒想到戈薇竟然輕而易舉地拔出來。不過問題是犬夜叉卻不懂得如何發揮鐵碎牙的威力，還把它認為是一把破破爛爛的刀子。直到犬夜叉決心要保護戈薇時,這把鐵碎牙竟然產生了脈動……

In the Kai Province, there is a young samurai named Nobunaga. He is a clumsy but earnest young man. He has heard rumors about the man that the the princess, his childhood friend, has married. Nobunaga tries to save the lord of the castle who is possessed by a toad demon.

Shippo is a demon fox whose father was killed by the the Thunder Brothers: Hiten and Manten. He steals the Shikon Jewel shards from Kagome so that he can avenge his father.

Inuyasha goes to save Kagome from Manten. Hiten devours the sacred jewel shard that Manten had and absorbs his demon powers. Hiten attacks Inuyasha with his Raigekijin. Inuyasha is in trouble and defends himself with the scabbard of the Tetsusaiga.

Kagome has returned to the present day to take a test. As she does, a noh mask, the Mask of Flesh, begins a violent search for the Shikon Jewel shards. Kagome's younger brother, Sota, tries hard to call Inuyasha to come to Kagome's rescue.

Kagome sees a Soul Piper, a demon that consoles the spirits of children. She helps Mayu, a girl who is about to become an evil spirit, to pass on.

Half demon Inuyasha's secret is that he becomes human once a month. That day, Inuyasha and the gang meet Nazuna and stay at a mountain temple. They fall into Kumogashira's trap and the sacred jewel shards are taken away from them. Inuyasha is injected with poison!

The ogress, Urasue, robs the grave of Kikyo, the priestess who sealed away Inuyasha fifty years ago. She revives Kikyo's body using the ashes of Kikyo's bones and soil from Kikyo's grave. But Kikyo's soul has already been reincarnated in a different body.

Kikyo is revived when Kagome's soul flows into her. She tries to kill Inuyasha, but Kagome takes back her soul. Fifty years ago, Kikyo wanted Inuyasha to use the Shikon Jewel to become human. But on the day of their promise, someone who looked like Inuyasha fatally injured Kikyo. Inuyasha realizes that there is a mysterious person who made them fight.

Miroku, a womanizing delinquent priest, has been collecting Shikon Jewel shards and steals Kagome's shards. Inuyasha tracks him down and confronts Miroku to get the shards back. Miroku fights back with his priestly powers and the wind tunnel in his hand that he was cursed with.

Kotatsu, a painter, sees a dream in which he becomes successful by controlling an army of ogres drawn with ink that has a sacred jewel shard in it. Miroku, Inuyasha and the others become involved in protecting the princess that Kotatsu is in love with.

Naraku appears before Sesshomaru and lends him an arm with a sacred jewel shard embedded in it. Sesshomaru attaches the arm to himself and appears before Inuyasha and the gang to steal the Tetsusaiga.

Sesshomaru wields the Tetsusaiga with his borrowed arm against Inuyasha, who fights back with his scabbard. When the two strike each other at the same time, Inuyasha gets up close to Sesshomaru, rips off his arm, and gets back the Tetsusaiga. When Inuyasha learns Naraku's plan, he fears that Kagome might die.

Kagome has her sacred jewel shards taken away from her and is returned to the present day, unable to return to feudal Japan. Back to her normal life, she agrees to go on a date with Hojo. Meanwhile, Inuyasha and the gang try to find out more about the mysterious Naraku.

Kagome returns to the shrine in the middle of her date with Hojo. She senses the presence of the Shikon Jewel shards and returns to feudal Japan. Naraku reveals that fifty years ago, Onigumo was in love with Kikyo. The demons that were drawn to Onigumo by his malice devoured Onigumo, and the demon Naraku was born.

Kikyo, who was brought back to life, is living as a priestess. A monk, who realizes that Kikyo is dead, tries to make Kikyo pass on, but Kikyo ends up killing him. Inuyasha saves the monk's disciples and runs to Kikyo when he hears the priestess's name.

Kikyo paralyzes Kagome. Inuyasha appears before her. Kikyo has been gathering the souls of dead girls. She vents her grudge against Inuyasha. Inuyasha reveals that he has never forgotten her. When Inuyasha kisses Kikyo, Kikyo tries to drag him to hell. But Inuyasha hears Kagome's voice and regains consciousness.

Sango, a demon slayer, is invited to Hitomi Castle along with her father, the leader of the demon slayers, and her younger brother, Kohaku. But it is a trap. Meanwhile, the undefended village is attacked by a horde of demons and annihilated. Naraku takes the Shikon Jewel shards that they had been gathering and leaves.

Sango fights Inuyasha, believing him to be her enemy. Naraku's plan is to have her fight to the death using the power of the Shikon Jewel shard. But Sango listens to Kagome and is no longer suspicious of Inuyasha.

Sango reveals the secret story of the Shikon Jewel's birth. Midoriko, a priestess with powerful spiritual powers, fused with many demons after a battle to the death. She absorbed the souls of the demons into her own, punched out her soul, and died. Her soul is the Shikon Jewel.

Inuyasha and the gang meet Taromaru, the son of a village leader. They go to the Temple of the Water God, where children are being sacrificed. The Water God has a sacred treasure and toys around with the group.