Professor Shepherd must call together a group of awesome dogs to stop General Parvo from gaining an important weapon. Shepard names his dogs the "Road Rovers," and they set off on their first mission: to duel the General Parvo, his Lieutenant Groomer, and the first two Cano-Mutants.

The Road Rovers travel to England to fight a group of werewolves wreaking havoc. They return to MissionControl seemingly safe, but when ""werewolfy"" things start happening there, it is obvious that one of their teammates is infected. But which Road Rover is it? And can they stop their infected comrade before he/she destroys mankind? (Not to mention devouring all their kibble!)

A small dog from San Francisco witnesses the kidnapping of his master! The Rovers find and rescue him, and he is trans-dogmified to go to court to testify with the aid of the Road Rovers, who have no idea what they are in for. Will they be caught themselves?

Parvo is now running an operation of kidnapped dogs! Colleen and Shag sneak themselves into the facility where they find not just a few dogs, but hundreds! Parvo's plan is to transform them into his servants at his leisure! How will Colleen and Shag escape? And will they rescue every single one of the dognapped pups?

The Groomer defies Parvo and retreats to Egypt with three of her felo-mutants! The Rovers must stop the new breed of enemies, the Felo-sapiens, (human cats). A startling revelation about an enemy is revealed when Groomer tries an ancient Egyptian ritual to grant herself eternal life.

After discovering an amazing tool, Parvo goes back in time in the form of a cat! He becomes the pet of Professor William Shepherd, who is just perfecting his Trans-Dogmifier. Parvo plans to derail Shepard's ideas, thus ruining the future of Road Rovers! Parvo's past is revealed as the Rovers hunt him down.

The Rovers' owners - the world leaders - are brainwashed into warring with one another because of an extra-terrestrial force! It is up to the Road Rovers to save them, and the whole world from nuclear war!